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Titolo:
Lateralization of brain activation to imagination and smell of odors usingfunctional magnetic resonance imaging (fMRI): Left hemispheric localization of pleasant and right hemispheric localization of unpleasant odors
Autore:
Henkin, RI; Levy, LM;
Indirizzi:
Taste & Smell Clin, Washington, DC 20016 USA Taste & Smell Clin Washington DC USA 20016 Clin, Washington, DC 20016 USA Georgetown Univ, Med Ctr, Dept Radiol, Washington, DC 20007 USA GeorgetownUniv Washington DC USA 20007 Radiol, Washington, DC 20007 USA
Titolo Testata:
JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY
fascicolo: 4, volume: 25, anno: 2001,
pagine: 493 - 514
SICI:
0363-8715(200107/08)25:4<493:LOBATI>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; PLANUM-TEMPORALE ASYMMETRY; HUMAN OLFACTORY CORTEX; CEREBRAL BLOOD-FLOW; SEX-DIFFERENCES; CORPUS-CALLOSUM; HUMAN AMYGDALA; MRI FMRI; RAT PUPS; MEMORY;
Keywords:
olfaction; brain; brain lateralization; magnetic resonance imaging; cognition; imagination;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
204
Recensione:
Indirizzi per estratti:
Indirizzo: Henkin, RI Taste & Smell Clin, 5125 MacArthur Blvd NW, Washington, DC 20016 USA Taste & Smell Clin 5125 MacArthur Blvd NW Washington DC USA 20016
Citazione:
R.I. Henkin e L.M. Levy, "Lateralization of brain activation to imagination and smell of odors usingfunctional magnetic resonance imaging (fMRI): Left hemispheric localization of pleasant and right hemispheric localization of unpleasant odors", J COMPUT AS, 25(4), 2001, pp. 493-514

Abstract

Purpose: Our goal was to use functional MRI (fMRI) of brain to reveal activation in each cerebral hemisphere in response to imagination and smell of odors. Method: FMRI brain scans were obtained in 24 normal subjects using multislice fast low angle shot (FLASH) MRI in response to imagination of banana and pepper mint odors and in response to smell of corresponding odors of amylacetate and menthone, respectively, and of pyridine. Three coronal sections selected from anterior to posterior brain regions were used. Similar studies were obtained in two patients with hyposmia using FLASH MRI and in one patient with hyposmia using echo planar imaging (EPI) both before and aftertheophylline treatment that returned smell function to or toward normal ineach patient and in two patients with birhinal phantosmia (persistent foulodor) and global phantogeusia (persistent foul taste) with FLASH and EPI fMRI before and after treatment with neuroleptic drugs that inhibited their phantosmia and phantogeusia. Activation images were derived using correlation analysis. Ratios of hemispheric areas of brain activation to total hemispheric brain areas were calculated for FLASH fh IRI, and numerical counts of pixel clusters in each hemisphere were made for EPI studies. Total pixel cluster counts in localized regions of each hemispheric section were also obtained. Results: In normal subjects, activation generally occurred in left (L) > right (R) brain hemisphere in response to banana and peppermint odor imagination and to smell of corresponding odors of amyl acetate and menthone. Whereas there were no overall hemispheric differences for pyridine odor, activation in men was R > L hemisphere. Although absolute activation in both L and R hemispheres in response to banana odor imagination and amyl acetate smell was men > women, the ratio of L to R activation was women > men. In hyposmic patients studied by FLASH fMRI, activation to banana odor imagination and amyl acetate smell was L > R hemisphere both before and after theophylline treatment. In the hyposmic patient studied with EPI before theophyllinetreatment, activation to banana and peppermint odor imagination and to amyl acetate, menthone, and pyridine smell was R > L hemisphere; after theophylline treatment restored normal smell function, activation shifted completely with banana and peppermint odor imagination and amyl acetate and menthone smell to L > R hemisphere, consistent with responses in normal subjects. However, this shift also occurred for pyridine smell, which is opposite to responses in normal control subjects. In patients with phantosmia and phantogeusia, activation to phantosmia and phantogeusia before treatment was R >L hemisphere; after treatment inhibited phantosmia and phantogeusia, activation shifted with a slight L > R hemispheric lateralization. Localization of all lateralized responses indicated that anterior frontal and temporal cortices were brain regions most involved with imagination and smell of odors and with phantosmia and phantogeusia presence. Conclusion: Imagination and smell of odors perceived as pleasant generallyactivated the dominant or L > R brain hemisphere. Smell of odors perceivedas unpleasant and unpleasant phantosmia and phantogeusia generally activated the contralateral or R > L brain hemisphere. With remission of phantosmia and phantogeusia, hemispheric activation was not only inhibited, but alsothere was a slight shift to L > R hemispheric predominance. Predominant L > R hemispheric differences in brain activation in normal subjects occurredin the order amyl acetate > menthone > pyridine, consistent with the hypothesis that pleasant odors are more appreciated in L hemisphere and unpleasant odors more in R hemisphere. Anterior frontal and temporal cortex regionspreviously found activated by imagination and smell of odors and phantosmia and phantogeusia perception accounted for most hemispheric differences.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 09:48:26