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Titolo:
A model of a segmental oscillator in the leech heartbeat neuronal network
Autore:
Hill, AAV; Lu, J; Masino, MA; Olsen, OH; Calabrese, RL;
Indirizzi:
Emory Univ, Dept Biol, Atlanta, GA 30322 USA Emory Univ Atlanta GA USA 30322 ry Univ, Dept Biol, Atlanta, GA 30322 USA
Titolo Testata:
JOURNAL OF COMPUTATIONAL NEUROSCIENCE
fascicolo: 3, volume: 10, anno: 2001,
pagine: 281 - 302
SICI:
0929-5313(2001)10:3<281:AMOASO>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
GRADED SYNAPTIC TRANSMISSION; CENTRAL PATTERN GENERATOR; MEDICINAL LEECH; INTERSEGMENTAL COORDINATION; ELEMENTAL OSCILLATOR; COMPARTMENTAL MODEL; HIRUDO-MEDICINALIS; TIMING OSCILLATION; SWIMMERET SYSTEM; INTERNEURONS;
Keywords:
Hirudo medicinalis; half-center oscillator; central pattern generator;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Hill, AAV Emory Univ, Dept Biol, 1510 Clifton Rd, Atlanta, GA 30322 USA Emory Univ 1510 Clifton Rd Atlanta GA USA 30322 ta, GA 30322 USA
Citazione:
A.A.V. Hill et al., "A model of a segmental oscillator in the leech heartbeat neuronal network", J COMPUT N, 10(3), 2001, pp. 281-302

Abstract

We modeled a segmental oscillator of the timing network that paces the heartbeat of the leech. This model represents a network of six heart interneurons that comprise the basic rhythm-generating network within a single ganglion. This model builds on a previous two cell model (Nadim et al., 1995) byincorporating modifications of intrinsic and synaptic currents based on the results of a realistic waveform voltage-clamp study (Olsen and Calabrese,1996). Due to these modifications, the new model behaves more similarly tothe biological system than the previous model. For example, the slow-wave oscillation of membrane potential that underlies bursting is similar in form and amplitude to that of the biological system. Furthermore, the new model with its expanded architecture demonstrates how coordinating interneuronscontribute to the oscillations within a single ganglion, in addition to their role of intersegmental coordination.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 06:34:42