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Titolo:
Comparative study of cardiac troponin I and T measurements in a routine extra-cardiological clinical setting
Autore:
Pagani, F; Bonetti, G; Panteghini, M;
Indirizzi:
Spedali Civili, Azienda Osped, Lab Anal Chim Clin 1, I-25125 Brescia, Italy Spedali Civili Brescia Italy I-25125 Chim Clin 1, I-25125 Brescia, Italy
Titolo Testata:
JOURNAL OF CLINICAL LABORATORY ANALYSIS
fascicolo: 4, volume: 15, anno: 2001,
pagine: 210 - 214
SICI:
0887-8013(2001)15:4<210:CSOCTI>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONGESTIVE-HEART-FAILURE; CREATINE-KINASE-MB; SKELETAL-MUSCLE; MARKERS; ASSAY; SERUM;
Keywords:
diagnosis; laboratory; myocardial infarction; sensitivity and specificity; troponin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Panteghini, M Spedali Civili, Azienda Osped, Lab Anal Chim Clin 1, I-25125Brescia, Italy Spedali Civili Brescia Italy I-25125 -25125 Brescia, Italy
Citazione:
F. Pagani et al., "Comparative study of cardiac troponin I and T measurements in a routine extra-cardiological clinical setting", J CL LAB AN, 15(4), 2001, pp. 210-214

Abstract

This study compared troponin I (cTnl) to troponin T (cTnT) in a populationadmitted to General Medicine Divisions in whom acute myocardial infarction(AMI) was suspected; 98 consecutive patients were included. Diagnoses weremade without knowledge of troponin results: 51 patients had AMI, and 47 (including 8 with unstable angina) had no AMI. Patients were considered to betroponin positive if the marker concentration was > 99th percentile value of the reference population, Both troponins were associated with an almost absolute sensitivity for AMI (100% for cTnl and 98.0% for cTnT), while the specificity was marginally higher for cTnl (78.7% vs. 68.1%). Increased cTnl and/or cTnT were observed in 15 patients out of 39 without acute coronarysyndromes. Simultaneous positivity was seen in 8 patients with severe disorders and complications. Discordances were more frequent in favor of increased cTnT (n = 5) than the opposite (n = 2), even if this difference did notachieve statistical significance. cTnl and cTnT detected AMI with comparable efficiency. Cases without coronary syndrome positively concordant for troponins confirmed the ability of these biomarkers to detect myocardial injury undetectable by conventional diagnostic approaches. (C) 2001 Wiley-Liss,Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 12:48:23