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Titolo:
Comparison of a continuous glucose-insulin-potassium infusion versus intermittent bolus application of insulin on perioperative glucose control and hormone status in insulin-treated type 2 diabetics
Autore:
Hemmerling, TM; Schmid, MC; Schmidt, J; Kern, S; Jacobi, KE;
Indirizzi:
Univ Erlangen Nurnberg, Dept Anesthesiol, Erlangen, Germany Univ Erlangen Nurnberg Erlangen Germany Anesthesiol, Erlangen, Germany
Titolo Testata:
JOURNAL OF CLINICAL ANESTHESIA
fascicolo: 4, volume: 13, anno: 2001,
pagine: 293 - 300
SICI:
0952-8180(200106)13:4<293:COACGI>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
RENAL THRESHOLD; IV-INSULIN; SURGERY; MANAGEMENT; MELLITUS; PATIENT; PERIOD;
Keywords:
diabetes mellitus; insulin-treated type 2 diabetics; perioperative management; continuous GIK regimen; intermittent bolus application;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Hemmerling, TM CHUM, Hotel Dieu, 3840 Rue St Urbain, Montreal, PQ H2Y 1T8,Canada CHUM 3840 Rue St Urbain Montreal PQ Canada H2Y 1T8 , Canada
Citazione:
T.M. Hemmerling et al., "Comparison of a continuous glucose-insulin-potassium infusion versus intermittent bolus application of insulin on perioperative glucose control and hormone status in insulin-treated type 2 diabetics", J CLIN ANES, 13(4), 2001, pp. 293-300

Abstract

Study Objective: To compare the effect of two different perioperative insulin management regimes on patients undergoing either major surgery (vascular surgery) or minor surgery (vitrectomy). Design: Prospective, double-blind randomized trial. Patients: 48 insulin-treated type 2 diabetics aged IS to 85 years were studied. Setting: University medical center. Interventions: Patients were divided into four groups of 12 patients each:Groups A and B (major surgery), Groups C and D (minor surgery). Group A and C patients were treated with a continuous modified glucose-insulin-potassium infusion according to blood glucose levels after intubation. Patients assigned to Groups B and D were treated with intermittent intravenous (IV) insulin injections when glucose levels exceeded 12 mmol L-1. Measurements: Glucose and potassium levels were measured every 15 minutes and 30 minutes during surgery and up to 4 hours post-surgery. Plasma levels of lactate, cortisol, glycerol, and free fatty acids were measured in arterial samples after intubation (S1), after extubation (S2), and 4 hours after surgery (S3). Main Results: There were no significant differences of the patient characteristics among the four groups. There was no significant difference in the time course of plasma glucose level and hormone variables measured among the four groups. One episode of hyperglycemia in Group D during the postoperative period was treated with 12 IV units of insulin. One patient in Group Aand one in Group B received potassium intraoperatively (15 and 29 mmoL, respectively). Postoperatively, two other patients of Group A received 19 and12,5 mmoL, respectively, and one of Group B received 20 mmoL potassium.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 18:28:49