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Titolo:
Systematic analysis of acid, neutral and basic drugs in horse plasma by combination of solid-phase extraction, non-aqueous partitioning and gas chromatography-mass spectrometry
Autore:
Takeda, A; Tanaka, H; Shinohara, T; Ohtake, I;
Indirizzi:
Racing Chem Lab, Utsunomiya, Tochigi 3200851, Japan Racing Chem Lab Utsunomiya Tochigi Japan 3200851 , Tochigi 3200851, Japan
Titolo Testata:
JOURNAL OF CHROMATOGRAPHY B
fascicolo: 2, volume: 758, anno: 2001,
pagine: 235 - 248
SICI:
1387-2273(20010715)758:2<235:SAOANA>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
TOXICOLOGICAL INTEREST; RETENTION INDEXES; WHOLE-BLOOD; URINE; METABOLITES; AGONISTS; COLUMNS;
Keywords:
doping drugs; 1-(N,N-diisopropylamino)-n-alkanes;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Takeda, A Racing Chem Lab, 1731-2 Tsurutamachi, Utsunomiya, Tochigi 3200851, Japan Racing Chem Lab 1731-2 Tsurutamachi Utsunomiya Tochigi Japan 3200851
Citazione:
A. Takeda et al., "Systematic analysis of acid, neutral and basic drugs in horse plasma by combination of solid-phase extraction, non-aqueous partitioning and gas chromatography-mass spectrometry", J CHROMAT B, 758(2), 2001, pp. 235-248

Abstract

A sample preparation method for mass chromatographic detection of doping drugs from horst plasma is described. Bond Elut Certify (1 g/6 ml) is used for the extraction of 4 ml of horst: plasma. Fractionation is performed with6 ml of CHCl3-Me2CO (8:1) and 5 ml of 1% TEA-MeOH according to its property. Simple and effective clean-up based on non-aqueous partitioning is adopted to remove co-eluted contaminants in both acid and basic fractions. Two kinds of 1-(N,N-diisopropylamino)-n-alkanes are co-injected with the sample into the GC-MS system for the calculation of the retention index. Total recoveries of 107 drugs are examined. Some data of post administration plasma are presented. This procedure achieves sufficient recoveries and clean extracts for GC-MS analysis. The method is able to detect ng/ml drug levels in horse plasma. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 16:00:01