Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Simultaneous determination of olanzapine, clozapine and demethylated metabolites in serum by on-line column-switching high-performance liquid chromatography
Autore:
Weigmann, H; Hartter, S; Maehrlein, S; Kiefer, W; Kramer, G; Dannhardt, G; Hiemke, C;
Indirizzi:
Univ Mainz, Dept Psychiat, D-55131 Mainz, Germany Univ Mainz Mainz Germany D-55131 , Dept Psychiat, D-55131 Mainz, Germany Univ Mainz, Dept Pharm, D-55099 Mainz, Germany Univ Mainz Mainz Germany D-55099 inz, Dept Pharm, D-55099 Mainz, Germany
Titolo Testata:
JOURNAL OF CHROMATOGRAPHY B
fascicolo: 1, volume: 759, anno: 2001,
pagine: 63 - 71
SICI:
1387-2273(20010805)759:1<63:SDOOCA>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
REFRACTORY SCHIZOPHRENIC-PATIENTS; SOLID-PHASE EXTRACTION; HUMAN-PLASMA; AUTOMATED-DETERMINATION; ULTRAVIOLET DETECTION; MAJOR METABOLITES; N-DESMETHYLCLOZAPINE; CLINICAL-RESPONSE; ELECTROCHEMICAL DETECTION; PSYCHOTROPIC-DRUGS;
Keywords:
olanzapine; clozapine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Hiemke, C Univ Mainz, Dept Psychiat, Untere Zahlbacher str 8, D-55131 Mainz, Germany Univ Mainz Untere Zahlbacher str 8 Mainz Germany D-55131 ermany
Citazione:
H. Weigmann et al., "Simultaneous determination of olanzapine, clozapine and demethylated metabolites in serum by on-line column-switching high-performance liquid chromatography", J CHROMAT B, 759(1), 2001, pp. 63-71

Abstract

An automated method for simultaneous routine quantification of the antipsychotic drugs clozapine, olanzapine and their demethylated metabolites is described. The method included adsorption on a cyanopropyl (CPS) coated clean-up column (10 mum; 10X2.0 mm I.D.), washing off interfering serum constituents to waste, and separation on C18 ODS Hypersil reversed phase material (5 mum; 250x4.6 mm I.D.) using acetonitrile-water-tetramethylethylenediamine(37:62.6:0.4, v/v/v) adjusted to pH 6.5 with concentrated acetic acid. W-detection was performed at 254 nm. The Limit of quantification was 10-20 ng/ml. Relative day to day standard variations ranged between 4.5 and 13.5%. The method is suitable for routine monitoring of olanzapine and clozapine including their demethylated metabolites. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/11/19 alle ore 02:28:14