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Titolo:
Neuronal NOS inhibitor that reduces oxidative DNA lesions and neuronal sensitivity increases the expression of intact c-fos transcripts after brain injury
Autore:
Cui, JK; Liu, PK;
Indirizzi:
Baylor Coll Med, Dept Neurosurg, Houston, TX 77030 USA Baylor Coll Med Houston TX USA 77030 ept Neurosurg, Houston, TX 77030 USA Baylor Coll Med, Dept Mol & Cell Biol, Houston, TX 77030 USA Baylor Coll Med Houston TX USA 77030 l & Cell Biol, Houston, TX 77030 USA Baylor Coll Med, Dept Med, Cardiovasc Dis Program, Houston, TX 77030 USA Baylor Coll Med Houston TX USA 77030 c Dis Program, Houston, TX 77030 USA
Titolo Testata:
JOURNAL OF BIOMEDICAL SCIENCE
fascicolo: 4, volume: 8, anno: 2001,
pagine: 336 - 341
SICI:
1021-7770(200107/08)8:4<336:NNITRO>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
NERVE GROWTH-FACTOR; FOREBRAIN ISCHEMIA-REPERFUSION; FOCAL CEREBRAL-ISCHEMIA; PROGRAMMED CELL-DEATH; IN-SITU DETECTION; MESSENGER-RNA; GENE-EXPRESSION; RAT-BRAIN; ALZHEIMERS-DISEASE; MITOCHONDRIAL-DNA;
Keywords:
gene expression; neuroregeneration; oxidative stress; stroke; transcription;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Liu, PK Baylor Coll Med, Dept Neurosurg, 6560 Fannin,Suite 944, Houston, TX 77030 USA Baylor Coll Med 6560 Fannin,Suite 944 Houston TX USA 77030 030 USA
Citazione:
J.K. Cui e P.K. Liu, "Neuronal NOS inhibitor that reduces oxidative DNA lesions and neuronal sensitivity increases the expression of intact c-fos transcripts after brain injury", J BIOMED SC, 8(4), 2001, pp. 336-341

Abstract

In response to oxidative stress, the ischemic brain induces immediate early genes when its nuclear genes contain gene damage. Antioxidant that reduces gene damage also reduces cell death. To study the mechanism of neuronal sensitivity, we investigated the transcription of the c-fos gene after braininjury of the ischemia-reperfusion type using focal cerebral ischemia-reperfusion in Long-Evans hooded rats. We observed a significant (p < 0.01) increase in c-fos mRNA in the ischemic cortex immediately after brain injury. However, the c-fos transcript was sensitive to RNase A protection assay (RPA) upon reperfusion. The transcript became significantly resistant to RPA (42%, p < 0.03) when 3-bromo-7-nitroindazole (25 mg/kg, i.p.), known to abolish nitric oxide, gene damage and neuronal sensitivity, was injected. Our data suggest that neuronal nitric oxide synthase and aberrant mRNA from genes with oxidative damage could be associated with neuronal sensitivity. Copyright (C) 2001 National Science council, ROC and S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 18:40:33