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Titolo:
Transactivation specificity of glucocorticoid versus progesterone receptors - Role of functionally different interactions of transcription factors with amino- and carboxyl-terminal receptor domains
Autore:
Song, LN; Huse, B; Rusconi, S; Simons, SS;
Indirizzi:
NIDDK, Steroid Hormones Sect, LMCB, NIH, Bethesda, MD 20892 USA NIDDK Bethesda MD USA 20892 mones Sect, LMCB, NIH, Bethesda, MD 20892 USA Univ Fribourg, CH-1700 Fribourg, Switzerland Univ Fribourg Fribourg Switzerland CH-1700 CH-1700 Fribourg, Switzerland
Titolo Testata:
JOURNAL OF BIOLOGICAL CHEMISTRY
fascicolo: 27, volume: 276, anno: 2001,
pagine: 24806 - 24816
SICI:
0021-9258(20010706)276:27<24806:TSOGVP>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
THYROID-HORMONE RECEPTOR; TUMOR VIRUS PROMOTER; PARTIAL AGONIST ACTIVITY; HUMAN ESTROGEN-RECEPTOR; BREAST-CANCER CELLS; NUCLEAR RECEPTOR; ANDROGEN RECEPTOR; GENE-EXPRESSION; DNA-BINDING; STEROID-RECEPTORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
89
Recensione:
Indirizzi per estratti:
Indirizzo: Simons, SS NIDDK, Steroid Hormones Sect, LMCB, NIH, Bldg 8,Rm B2A-07, Bethesda, MD 20892 USA NIDDK Bldg 8,Rm B2A-07 Bethesda MD USA 20892 esda, MD 20892 USA
Citazione:
L.N. Song et al., "Transactivation specificity of glucocorticoid versus progesterone receptors - Role of functionally different interactions of transcription factors with amino- and carboxyl-terminal receptor domains", J BIOL CHEM, 276(27), 2001, pp. 24806-24816

Abstract

A major unanswered question of glucocorticoid and progesterone action is how different whole cell responses arise when both of the cognate receptors can bind to, and activate, the same hormone response elements. We have documented previously that the EC,, of agonist complexes, and the partial agonist activity of antagonist complexes, of both glucocorticoid receptors (GRs)and progesterone receptors (PRs) are modulated by increased amounts of homologous receptor and of coregulators. We now ask whether these components can differentially alter GR and PR transcriptional properties. To remove possible cell-specific differences, we have examined both receptors in the common environment of a line of mouse mammary adenocarcinoma (1470.2) cells, In order to segregate the responses that might be due to unequal nucleosome reorganization by the two receptors from those reflecting interactions withother components, we chose a transiently transfected reporter containing asimple glucocorticoid response element (i.e. GREtkLUC), No significant differences are found with elevated levels of either receptor. However, major,qualitative differences are seen with the corepressors SMRT and NCoR, which afford opposite responses with GR and PR. Studies with chimeric GR/PR receptors indicate that no one segment of PR or G;R is responsible for these properties and that the composite response likely involves interactions withboth the amino and carboxyl termini of receptors, Collectively, the data suggest that GR and PR induction of responsive genes in a given cell can be differentially controlled, in part, by unequal interactions of multiple receptor domains with assorted nuclear cofactors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 23:44:53