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Titolo:
Cyclothymia or unstable mood disorder? A systematic treatment evaluation with valproic acid
Autore:
Verhoeven, WMA; Tuinier, S;
Indirizzi:
Vincent van Gogh Inst Psychiat, NL-5803 AC Venray, Netherlands Vincent vanGogh Inst Psychiat Venray Netherlands NL-5803 AC Netherlands Erasmus Univ, Fac Med & Med Sci, NL-3015 GE Rotterdam, Netherlands ErasmusUniv Rotterdam Netherlands NL-3015 GE GE Rotterdam, Netherlands
Titolo Testata:
JOURNAL OF APPLIED RESEARCH IN INTELLECTUAL DISABILITIES
fascicolo: 2, volume: 14, anno: 2001,
pagine: 147 - 154
SICI:
1360-2322(2001)14:2<147:COUMDA>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
SELF-INJURIOUS-BEHAVIOR; MENTAL-RETARDATION; INTELLECTUAL DISABILITY; BIPOLAR; PEOPLE; SCALE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Verhoeven, WMA Vincent van Gogh Inst Psychiat, Stn Weg 46, NL-5803 AC Venray, Netherlands Vincent van Gogh Inst Psychiat Stn Weg 46 Venray Netherlands NL-5803 AC
Citazione:
W.M.A. Verhoeven e S. Tuinier, "Cyclothymia or unstable mood disorder? A systematic treatment evaluation with valproic acid", J APPL RES, 14(2), 2001, pp. 147-154

Abstract

Cyclic changes in behaviour and mood which do not meet the criteria for bipolar affective disorder have been reported in people with intellectual disability (ID) since the beginning of the twentieth century. The present study postulates a functional disturbance of unstable mood disorder in such cases of an episodic pattern of disturbed behaviour, mood and anxiety. Since symptoms of hypomania or major depression are not observed in these individuals, the unstable mood disorder cannot be regarded as being part of the bipolar spectrum, although it resembles cyclothymia in some aspects. In this pilot study, 28 subjects with ID were treated with valproic acid in dosages leading to a mean plasma concentration of 63 mg L-1. A marked and sustainedimprovement was achieved in 68% of subjects in terms of both behaviour stability, and a reduction of symptoms in the mood, anxiety and motor domains.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 08:01:51