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Titolo:
Mismatched human leukocyte antigen alleles protect against heterosexual HIV transmission
Autore:
Lockett, SF; Robertson, JR; Brettle, RP; Yap, PL; Middleton, D; Brown, AJL;
Indirizzi:
Univ Edinburgh, Ctr HIV Res, Inst Cell Anim & Populat Biol, Edinburgh, Midlothian, Scotland Univ Edinburgh Edinburgh Midlothian Scotland burgh, Midlothian, Scotland Univ Edinburgh, Edinburgh Drug Addict Study, Muirhouse Med Grp, Edinburgh,Midlothian, Scotland Univ Edinburgh Edinburgh Midlothian Scotland nburgh,Midlothian, Scotland Univ Edinburgh, Dept Gen Practice, Edinburgh, Midlothian, Scotland Univ Edinburgh Edinburgh Midlothian Scotland burgh, Midlothian, Scotland Western Gen Hosp, Reg Infect Dis Unit, Edinburgh EH4 2XU, Midlothian, Scotland Western Gen Hosp Edinburgh Midlothian Scotland EH4 2XU dlothian, Scotland Royal Infirm, Scottish Natl Blood Transfus Serv, Edinburgh, Midlothian, Scotland Royal Infirm Edinburgh Midlothian Scotland inburgh, Midlothian, Scotland City Hosp, No Ireland Reg Histocompatibil & Immunogenet Lab, Belfast, Antrim, North Ireland City Hosp Belfast Antrim North Ireland b, Belfast, Antrim, North Ireland
Titolo Testata:
JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
fascicolo: 3, volume: 27, anno: 2001,
pagine: 277 - 280
SICI:
1525-4135(20010701)27:3<277:MHLAAP>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNODEFICIENCY-VIRUS; INFECTION; HLA; RESISTANCE; CHALLENGE; MACAQUES; DELETION; GENE;
Keywords:
major histocompatibility complex; HIV; heterozygosity; sexual transmission;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Brown, AJL Univ Calif San Diego, Dept Pathol, Treatment Ctr, 150 W Washington St, SanDiego, CA 92103 USA Univ Calif San Diego 150 W Washington St SanDiego CA USA 92103
Citazione:
S.F. Lockett et al., "Mismatched human leukocyte antigen alleles protect against heterosexual HIV transmission", J ACQ IMM D, 27(3), 2001, pp. 277-280

Abstract

Genetic variation at the human leukocyte antigen (HLA) loci has been shownto he an important risk factor for progression to HIV disease, but its significance in infection is less well understood. We have investigated its role in HIV transmission in a cohort of individuals at risk for heterosexual infection. Analysis of over 80 individuals revealed that that the degree ofconcordance at HLA A, B, and DR loci differs significantly between transmitting and nontransmitting couples at risk for heterosexual HIV transmission(p < .02), suggesting that allogeneic immune responses may confer a degreeof protection against HIV infection. Analysis of the frequencies of specific alleles at the A, B, and DR loci revealed a significantly higher frequency of HLA DR5 among exposed uninfected individuals, relative to population controls.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 00:14:34