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Titolo:
Detrimental effects of continued illicit drug use on the treatment of HIV-1 infection
Autore:
Lucas, GM; Cheever, LW; Chaisson, RE; Moore, RD;
Indirizzi:
Johns Hopkins Univ, Sch Med, Baltimore, MD USA Johns Hopkins Univ Baltimore MD USA ins Univ, Sch Med, Baltimore, MD USA Hlth Resources & Serv Adm, Rockville, MD USA Hlth Resources & Serv Adm Rockville MD USA & Serv Adm, Rockville, MD USA
Titolo Testata:
JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
fascicolo: 3, volume: 27, anno: 2001,
pagine: 251 - 259
SICI:
1525-4135(20010701)27:3<251:DEOCID>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACTIVE ANTIRETROVIRAL THERAPY; IMMUNODEFICIENCY-VIRUS INFECTION; METHADONE-MAINTENANCE PROGRAM; VIROLOGICAL FAILURE; RISK-FACTORS; CLINICAL PROGRESSION; PRIMARY-CARE; ADHERENCE; RESISTANCE; RNA;
Keywords:
antiretroviral therapy; CD4(+) lymphocyte count; HIV-1; illicit drug use; patient nonadherence; viral load;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Lucas, GM 1830 E Monument St,Room 457, Baltimore, MD 21287 USA 1830 E Monument St,Room 457 Baltimore MD USA 21287 MD 21287 USA
Citazione:
G.M. Lucas et al., "Detrimental effects of continued illicit drug use on the treatment of HIV-1 infection", J ACQ IMM D, 27(3), 2001, pp. 251-259

Abstract

Objective: To identify the effects of substance abuse status (active. former, and never) on utilization of highly active antiretroviral therapy (HAART), medication adherence, and virologic and immunologic responses to therapy. Design: Prospective cohort study of 764 HIV-1-infected patients who attended an urban HIV clinic and participated in a standardized interview. Main Outcome Measures: Past utilization of HAART, self-reported nonadherence with antiretroviral therapy, and changes in HIV-1 RNA level and CD4(+) lymphocyte count relative to prior peak and nadir, respectively. Results: Forty-four percent of active drug users failed to utilize HAART compared with 22% of former drug users and 18% of non-drug users (p < .001 for both comparisons). Among participants: who were taking antiretroviral therapy when interviewed, active drug users were more likely to report medication nonadherence (34% vs. 24% of nonusers and 17% of former users), had a smaller median reduction in HIV-I RNA from baseline (0.8 log(10) copies/ml vs. 1.7 in nonusers and 1.6 in former users), and had smaller median increases in CD4(+) lymphocyte count from baseline (65 cells/mm(3) vs. 116 in nonusers and 122 in former users) (p < .05 for all comparisons with active users). Conclusions: Active drug use was strongly associated with underutilizationof HAART, nonadherence, and inferior virologic and immunologic responses to therapy, whereas former drug users and non-drug users were similar in alloutcomes. Effective strategies Lire needed that integrate HIV-I and substance abuse treatments.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 03:23:03