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Titolo:
Intraocular pressure responses to the adenosine agonist cyclohexyladenosine: Evidence for a dual mechanism of action
Autore:
Crosson, CE;
Indirizzi:
Med Univ S Carolina, Dept Ophthalmol, Ola B Williams Glaucoma Therapeut Dev Ctr, Storm Eye Inst, Charleston, SC 29425 USA Med Univ S Carolina Charleston SC USA 29425 nst, Charleston, SC 29425 USA
Titolo Testata:
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
fascicolo: 8, volume: 42, anno: 2001,
pagine: 1837 - 1840
SICI:
0146-0404(200107)42:8<1837:IPRTTA>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
AQUEOUS-HUMOR DYNAMICS; RECEPTOR ACTIVATION; MOLECULAR-CLONING; RELEASE; RABBITS; RETINA; CELLS; A(1); CDNA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Crosson, CE Med Univ S Carolina, Dept Ophthalmol, Ola B Williams Glaucoma Therapeut Dev Ctr, Storm Eye Inst, 171 Ashley Ave, Charleston, SC 29425 USAMed Univ S Carolina 171 Ashley Ave Charleston SC USA 29425 USA
Citazione:
C.E. Crosson, "Intraocular pressure responses to the adenosine agonist cyclohexyladenosine: Evidence for a dual mechanism of action", INV OPHTH V, 42(8), 2001, pp. 1837-1840

Abstract

PURPOSE. Previous studies have shown that adenosine agonists are effectivein reducing intraocular pressure (IOP). However, the mechanism(s) responsible for this ocular hypotensive effect has not been established. This studyevaluates the relative contribution of changes in aqueous flow and outflowfacility associated with the ocular hypotensive response to the adenosine agonist cyclohexyladenosine (CHA). METHODS. New Zealand White rabbits were treated topically in one eye with the adenosine A(1) agonist CHA. Changes in IOP, aqueous flow, and total outflow facility at various times after CHA administration were then determined. RESULTS. These studies demonstrated that CHA produces a dose-related reduction in IOP. Analysis of the dose-response curve revealed an ED50, and a Hill coefficient of 87 mug and 1.9, respectively. Aqueous flow measurements demonstrated that 1.5 hours after CI-IA administration, aqueous now was reduced by 35%. However, by 3.5 hours postdrug, no significant change in aqueous flow was observed. Measurement of the outflow facility found no significant change in facility 1.5 hours after CHA administration. However, by 3.5 hours after CHA administration, outflow facility was significantly increasedby 85%. CONCLUSIONS. These data demonstrate that the adenosine agonist CHA lowers IOP in a dose-related fashion. This hypotensive action results from an early reduction in aqueous flow followed by a subsequent increase in outflow facility. This dual mechanism of action is consistent with analysis of CHA dose-response curve, which indicates that the reduction in IOP induced this agonist's results from multiple mechanisms of action.

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Documento generato il 02/04/20 alle ore 02:07:24