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Titolo:
Relationship between radiation-induced aberrations in individual chromosomes and their DNA content: effects of interaction distance
Autore:
Wu, H; Durante, M; Lucas, JN;
Indirizzi:
NASA, Lyndon B Johnson Space Ctr, Radiat Biophys Lab, Houston, TX 77058 USA NASA Houston TX USA 77058 Ctr, Radiat Biophys Lab, Houston, TX 77058 USA NASA, Lyndon B Johnson Space Ctr, Kelsey Seybold Clin, Houston, TX 77058 USA NASA Houston TX USA 77058 Ctr, Kelsey Seybold Clin, Houston, TX 77058 USA Univ Naples, Dept Phys, Naples, Italy Univ Naples Naples ItalyUniv Naples, Dept Phys, Naples, Italy Univ Calif Lawrence Livermore Natl Lab, Livermore, CA 94550 USA Univ CalifLawrence Livermore Natl Lab Livermore CA USA 94550 A 94550 USA
Titolo Testata:
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
fascicolo: 7, volume: 77, anno: 2001,
pagine: 781 - 786
SICI:
0955-3002(200107)77:7<781:RBRAII>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
IN-SITU HYBRIDIZATION; INDUCED STRUCTURAL-ABERRATIONS; IONIZING-RADIATION; INTERPHASE; FREQUENCY; INVOLVEMENT; LYMPHOCYTES; EXPOSURE; GEOMETRY; DOMAINS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Wu, H NASA, Lyndon B Johnson Space Ctr, Radiat Biophys Lab, Mail Code SD23, Houston, TX 77058 USA NASA Mail Code SD23 Houston TX USA 77058 SD23, Houston, TX 77058 USA
Citazione:
H. Wu et al., "Relationship between radiation-induced aberrations in individual chromosomes and their DNA content: effects of interaction distance", INT J RAD B, 77(7), 2001, pp. 781-786

Abstract

Purpose: To study the effect of the interaction distance on the frequency of inter- and intrachromosome exchanges in individual chromosomes with respect to their DNA content. Assumptions: Chromosome exchanges are formed by misrejoining of tw DNA double-strand breaks (DSB) induced within an interaction distance, d. It is assumed that chromosomes in G(o)/G(1) phase of the cell cycle occupy a spherical domain in a cell nucleus, with no spatial overlap between individual chromosome domains. Results: Formulae are derived for the probability of formation of inter-, as well as intra-, chromosome exchanges relating to the DNA content of the chromosome for a given interaction distance. For interaction distances <1 <mu>m, the relative frequency of interchromosome exchanges predicted by the present model is similar to that by Cigarran et al. (1998) based of the assumption that the probability of interchromosome exchanges is proportional to the 'surface area' of the chromosome territory. The 'surface area' assumption is shown to be a limiting case of d-->0 in the present model. The present model also predicts that the probability of intrachromosome exchanges occurring in individual chromosomes is proportional to their DNA content with correction terms. Conclusion: When the interaction distance is small, the 'surface area' distribution for chromosome participation in interchromosome exchanges has been expected. However, the present model shows that for the interaction distance as large as 1 mum, the predicted probability of interchromosome exchange formation is still close to the surface area distribution. Therefore, this distribution does not necessarily rule out the formation of complex chromosomal aberrations by long-range misrejoining of DSB.

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Documento generato il 02/04/20 alle ore 02:24:15