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Titolo:
Correlations between motor persistence and plasma levels in methylphenidate-treated boys with ADHD
Autore:
Greenhill, LL; Perel, JM; Rudolph, G; Feldman, B; Curran, S; Puig-Antich, J; Gardner, R;
Indirizzi:
Univ Pittsburgh, Western Psychiat Inst & Clin, Clin Pharmacol Program, Pittsburgh, PA 15213 USA Univ Pittsburgh Pittsburgh PA USA 15213 Program, Pittsburgh, PA 15213 USA Columbia Univ Coll Phys & Surg, New York, NY 10032 USA Columbia Univ Coll Phys & Surg New York NY USA 10032 w York, NY 10032 USA New York State Psychiat Inst, New York, NY 10032 USA New York State Psychiat Inst New York NY USA 10032 New York, NY 10032 USA
Titolo Testata:
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
fascicolo: 2, volume: 4, anno: 2001,
pagine: 207 - 215
SICI:
1461-1457(200106)4:2<207:CBMPAP>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEFICIT HYPERACTIVITY DISORDER; HYPERKINETIC CHILDREN; DOUBLE-BLIND; PHARMACOKINETICS; BEHAVIOR; MODELS;
Keywords:
methylphenidate; kinetic-dynamic; motor persistence; plasma level; ADHD;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Perel, JM Univ Pittsburgh, Western Psychiat Inst & Clin, Clin Pharmacol Program, 3811 Ohara St, Pittsburgh, PA 15213 USA Univ Pittsburgh 3811 Ohara St Pittsburgh PA USA 15213 15213 USA
Citazione:
L.L. Greenhill et al., "Correlations between motor persistence and plasma levels in methylphenidate-treated boys with ADHD", IN J NEUROP, 4(2), 2001, pp. 207-215

Abstract

Following a 0.9 mg/kg methylphenidate loading dose, serial plasma level determinations, self-scored mood ratings, and measures of motor persistence were gathered on eight previously unmedicated boys with attention deficit disorder with hyperactivity (ADHD) during a 9-h period. The measures were repeated using the same loading dose after 6 months of maintenance treatment with methylphenidate (1.3 mg/kg.d). Kinetic-dynamic modelling suggests inverse correlative relationships between motor performance errors and plasma levels. Pharmacokinetic parameters did not change between acute and maintenance drug treatment phases, and there was no evidence of long-term tolerance.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 01:28:04