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Titolo:
Brain anatomy and chemistry may predict treatment response in paediatric obsessive-compulsive disorder
Autore:
Rosenberg, DR; MacMillan, SN; Moore, GJ;
Indirizzi:
Wayne State Univ, Sch Med, Dept Psychiat & Behav Neurosci, Detroit, MI USAWayne State Univ Detroit MI USA ychiat & Behav Neurosci, Detroit, MI USA Wayne State Univ, Sch Med, Dept Radiol, Detroit, MI USA Wayne State Univ Detroit MI USA v, Sch Med, Dept Radiol, Detroit, MI USA Wayne State Univ, Sch Med, Dept Pediat, Detroit, MI USA Wayne State Univ Detroit MI USA v, Sch Med, Dept Pediat, Detroit, MI USA
Titolo Testata:
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
fascicolo: 2, volume: 4, anno: 2001,
pagine: 179 - 190
SICI:
1461-1457(200106)4:2<179:BAACMP>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN CORPUS-CALLOSUM; CAUDATE-NUCLEUS; BASAL GANGLIA; STRUCTURAL ABNORMALITIES; SEROTONIN RELEASE; PREFRONTAL CORTEX; SYDENHAMS CHOREA; VOLUME; TOMOGRAPHY; PAROXETINE;
Keywords:
obsessive-compulsive disorder; paediatric; child; neuroimaging; glutamate; thalamus; cortex; striatum;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
77
Recensione:
Indirizzi per estratti:
Indirizzo: Rosenberg, DR Psychiat 9B-21,4201 St Antoine Blvd, Detroit, MI 48201 USA Psychiat 9B-21,4201 St Antoine Blvd Detroit MI USA 48201 SA
Citazione:
D.R. Rosenberg et al., "Brain anatomy and chemistry may predict treatment response in paediatric obsessive-compulsive disorder", IN J NEUROP, 4(2), 2001, pp. 179-190

Abstract

Obsessive-compulsive disorder (OCD) is a severe, highly prevalent and often chronically disabling illness with frequent onset in childhood and adolescence. This underscores the importance of studying the illness during childhood near the onset of illness to minimize potential confounds of long-termillness duration and treatment intervention as well as to examine the developmental underpinnings of the illness. In this review, the authors focus on an integrated series of brain-imaging studies in paediatric OCD suggesting a reversible glutamatergically mediated thalamo-cortical-striatal dysfunction in OCD and their relevance for improved diagnosis and treatment of thecondition. Developmental neurobiological models for OCD are presented and particular attention is devoted to evaluating neuroimaging studies designedto test these models and how they may help predict treatment response in paediatric OCD.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 22:20:12