Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Biological studies in depressed children and adolescents
Autore:
Birmaher, B; Heydl, P;
Indirizzi:
Univ Pittsburgh, Med Ctr, Western Psychiat Inst & Clin, Pittsburgh, PA 15213 USA Univ Pittsburgh Pittsburgh PA USA 15213 & Clin, Pittsburgh, PA 15213 USA
Titolo Testata:
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
fascicolo: 2, volume: 4, anno: 2001,
pagine: 149 - 157
SICI:
1461-1457(200106)4:2<149:BSIDCA>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-HORMONE SECRETION; CORTICOTROPIN-RELEASING HORMONE; DEXAMETHASONE SUPPRESSION TEST; PREPUBERTAL MAJOR DEPRESSION; PLATELET IMIPRAMINE BINDING; PAST 10 YEARS; HIGH-RISK; AFFECTIVE-DISORDERS; SLEEP EEG; NEUROENDOCRINE RESPONSE;
Keywords:
major depressive disorder; children; adolescents; biology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
87
Recensione:
Indirizzi per estratti:
Indirizzo: Birmaher, B Univ Pittsburgh, Med Ctr, Western Psychiat Inst & Clin, 3811 OHara St, Pittsburgh, PA 15213 USA Univ Pittsburgh 3811 OHara St Pittsburgh PA USA 15213 5213 USA
Citazione:
B. Birmaher e P. Heydl, "Biological studies in depressed children and adolescents", IN J NEUROP, 4(2), 2001, pp. 149-157

Abstract

The objective was to review the literature on the biological correlates ofmajor depressive disorder (MDD) in children and adolescents. A computerized search for articles published during the last 20 years was done and selected studies presented. To date, examination of growth hormone IGH), prolactin, and cortisol levels after pharmacological stimulation have shown abnormalities in the secretion of these hormones (e.g. blunted GH secretion afterthe administration of growth hormone releasing hormone). Identical resultshave been found in never-depressed children at high risk to develop MDD due to high family loading for MDD suggesting that alteration in certain hormonal systems may be trait markers for MDD. Other biological studies (e.g. the hypothalamic-pituitary axis, sleep electroencephalogram) have yielded more inconsistent results with subjects with melancholic symptoms, severe depressions, and older age showing some abnormalities similar to the ones reported in adults with MDD. Factors such age, sex, maturation, psychiatric family history and exposure to stress need to be considered since they also affect the same biological systems associated with the aetiology of MDD. Considerable biological research has been done in youth with MDD. Further research is needed to investigate whet-her these markers predict the developmentof new episodes of MDD, recurrences, and treatment response. Also. these and other studies using more sophisticated methods (e.g. functional MRI) aimed at elucidating the interrelationship between biological and other risk factors are needed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 01:05:33