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Titolo:
Effect of fluoxetine on regional cerebral metabolism in autistic spectrum disorders: a pilot study
Autore:
Buchsbaum, MS; Hollander, E; Haznedar, MM; Tang, C; Spiegel-Cohen, J; Wei, TC; Solimando, A; Buchsbaum, BR; Robins, D; Bienstock, C; Cartwright, C; Mosovich, S;
Indirizzi:
CUNY Mt Sinai Sch Med, Neurosci PET Lab, New York, NY 10029 USA CUNY Mt Sinai Sch Med New York NY USA 10029 T Lab, New York, NY 10029 USA
Titolo Testata:
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
fascicolo: 2, volume: 4, anno: 2001,
pagine: 119 - 125
SICI:
1461-1457(200106)4:2<119:EOFORC>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON-EMISSION-TOMOGRAPHY; ANTERIOR CINGULATE; GLUCOSE-METABOLISM; PREFRONTAL CORTEX; DOUBLE-BLIND; SCHIZOPHRENIA; SERTRALINE; PLACEBO; BRAIN;
Keywords:
positron emission tomography; magnetic resonance imaging; selective serotonin reuptake inhibitor; cingulate gyrus; orbitofrontal cortex; autism; Asperger's syndrome;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Buchsbaum, MS CUNY Mt Sinai Sch Med, Neurosci PET Lab, Box 1505,4 Gustave L Levy Pl, NewYork, NY 10029 USA CUNY Mt Sinai Sch Med Box 1505,4 Gustave LLevy Pl New York NY USA 10029
Citazione:
M.S. Buchsbaum et al., "Effect of fluoxetine on regional cerebral metabolism in autistic spectrum disorders: a pilot study", IN J NEUROP, 4(2), 2001, pp. 119-125

Abstract

The regional metabolic effects of fluoxetine were examined in patients with autism spectrum disorders. Six adult patients with DSM-IV and Autism Diagnostic Interview (ADI) diagnoses of autism (n = 5) and Asperge's syndrome (n = 1), entered a 16-wk placebo-controlled cross-over trial of fluoxetine. The patients received F-18-deoxyglucose positron emission tomography with co-registered magnetic resonance imaging at baseline and at the end of the period of fluoxetine administration. After treatment, the patients showed significant improvement on the scores of the Yale-Brown Obsessive-Compulsive Scale - Obsessions subscale and the Hamilton Anxiety Scale; Clinical GlobalImpressions - Autism scores showed 3 of the patients much improved and 3 unchanged. Relative metabolic rates were significantly higher in the right frontal lobe following fluoxetine, especially in the anterior cingulate gyrus and the orbitofrontal cortex. Patients with higher metabolic rates in themedial frontal region and anterior cingulate when unmedicated were more likely to respond favourably to fluoxetine. These results are consistent withthose in depression indicating that higher cingulate gyrus metabolic ratesat baseline predict SRI response.

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Documento generato il 19/01/20 alle ore 06:06:00