Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Regional cerebral blood flow in cocaine- versus methamphetamine-dependent patients with a history of alcoholism
Autore:
Alhassoon, OM; Dupont, RM; Schweinsburg, BC; Taylor, MJ; Patterson, TL; Grant, I;
Indirizzi:
VA San Diego Healthcare Syst, Psychiat Serv 116A, San Diego, CA 92161 USA VA San Diego Healthcare Syst San Diego CA USA 92161 n Diego, CA 92161 USA Univ Calif San Diego, San Diego, CA 92103 USA Univ Calif San Diego San Diego CA USA 92103 iego, San Diego, CA 92103 USA San Diego State Univ, San Diego, CA 92182 USA San Diego State Univ San Diego CA USA 92182 Univ, San Diego, CA 92182 USA
Titolo Testata:
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
fascicolo: 2, volume: 4, anno: 2001,
pagine: 105 - 112
SICI:
1461-1457(200106)4:2<105:RCBFIC>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
EMISSION COMPUTERIZED-TOMOGRAPHY; AMPHETAMINE ABUSERS; POLYDRUG USERS; VERBAL MEMORY; BRAIN SPECT; PERFUSION; ABSTINENCE; ACTIVATION; DEMENTIA; RISK;
Keywords:
cocaine; methamphetamine; alcohol abuse; SPECT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Grant, I VA San Diego Healthcare Syst, Psychiat Serv 116A, San Diego, CA 92161 USA VA San Diego Healthcare Syst San Diego CA USA 92161 CA 92161 USA
Citazione:
O.M. Alhassoon et al., "Regional cerebral blood flow in cocaine- versus methamphetamine-dependent patients with a history of alcoholism", IN J NEUROP, 4(2), 2001, pp. 105-112

Abstract

Although abuse of cocaine or methamphetamine usually takes place in the context of heavy drinking, there is little information on the effects of suchsubstance use comorbidity on brain perfusion. We explored similarities anddifferences in the effects of these two drugs in combination with alcohol on brain function using SPECT. Global and regional cerebral blood flow (CBF) were examined in 7 abstinent cocaine-dependent alcoholics (CDA; mean age = 39.2 yr, S.D. = 9.2 yr), 7 abstinent methamphetamine-dependent alcoholics(MDA; mean age = 36.8 yr, S.D. = 5.0 yr), and 7 non-alcoholic/non-stimulant abusing controls (NAC; mean age = 37.3 yr, S.D. = 9.6 yr). MDA had significantly lower global CBF than CDA who, in rum, were significantly lower than NAG. In addition, CDA had abnormal perfusion in the superior posterior frontal region compared to NAG; while MDA did not display specific regional deficits. Therefore, it appears that cocaine alters the relationship betweenglobal and regional CBF in alcoholics, while methamphetamine does not.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/09/19 alle ore 23:36:53