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Titolo:
Pretreatment hemoglobin, platelet count, and prognosis in endometrial carcinoma
Autore:
Tamussino, KF; Gucer, F; Reich, O; Moser, F; Petru, E; Scholz, HS;
Indirizzi:
Graz Univ, Dept Obstet & Gynecol, A-8036 Graz, Austria Graz Univ Graz Austria A-8036 ept Obstet & Gynecol, A-8036 Graz, Austria
Titolo Testata:
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
fascicolo: 3, volume: 11, anno: 2001,
pagine: 236 - 240
SICI:
1048-891X(200105/06)11:3<236:PHPCAP>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECOMBINANT-HUMAN-ERYTHROPOIETIN; EPITHELIAL OVARIAN-CANCER; RADIATION-THERAPY; SERUM LEVELS; CERVICAL-CANCER; RENAL-FAILURE; LUNG-CANCER; STAGE-III; ANEMIA; THROMBOCYTOSIS;
Keywords:
anemia; endometrial cancer; thrombocytosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Tamussino, KF Graz Univ, Dept Obstet & Gynecol, Auenbruggerpl 14, A-8036 Graz, Austria Graz Univ Auenbruggerpl 14 Graz Austria A-8036 raz, Austria
Citazione:
K.F. Tamussino et al., "Pretreatment hemoglobin, platelet count, and prognosis in endometrial carcinoma", INT J GYN C, 11(3), 2001, pp. 236-240

Abstract

We analyzed whether a low preteatment hemoglobin level is a prognostic factor in endometrial cancer and whether it is associated with thrombocytosis. Two hundred and twelve patients with endometrial cancer treated with surgery were reviewed. Data were analyzed with Pearson's chi-squared test, Fisher's exact test in contingency tables, the Mann-Whitney LI-test, the Student's t-test, and Kaplan-Meier estimates. Multivariate analysis was performed with the log-rank test and the Cox proportional hazard model. Thirty-nine patients (18%) had a pretreatment hemoglobin value of <12.0 g/dL. These 39 patients had significantly higher rates of nonendometrioid histology, high-grade tumors, myometrial invasion of >50%, adnexal involvement, lymph-vascular space involvement, and advanced FIGO stage than patients with hemoglobingreater than or equal to 12.0 g/dL. The rate of thrombocytosis was significantly higher in patients with a low hemoglobin level (36% vs. 8%, P < 0.01). The overall 5-year survival rate of patients with low pretreatment hemoglobin was 59% compared with 89% for those with hemoglobin <greater than or equal to>12 g/dL (P < 0.01). In the multivariate analysis age, thrombocytosis, nonendometrioid histology, high-grade histology, and advanced FIGO stage were significantly associated with a poor prognosis whereas adnexal involvement, lymph-vascular space involvement, low hemoglobin and myometrial invasion were not. These data indicate that low pretreatment hemoglobin is a prognostic factor in patients with endometrial cancer and that it is associated with thrombocytosis. Low hemoglobin was strongly associated with other unfavorable prognostic factors so that it was significant in the univariatebut not the multivariate analysis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 06:58:02