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Titolo:
Distribution of HPV 53, HPV 73 and CP8304 in genital epithelial lesions with different grades of dysplasia
Autore:
Meyer, T; Arndt, R; Beckmann, ER; Padberg, B; Christophers, E; Stockfleth, E;
Indirizzi:
Inst Immunol Pathol & Mol Biol, D-22339 Hamburg, Germany Inst Immunol Pathol & Mol Biol Hamburg Germany D-22339 Hamburg, Germany Univ Kiel, Dept Dermatol, D-24098 Kiel, Germany Univ Kiel Kiel Germany D-24098 iel, Dept Dermatol, D-24098 Kiel, Germany
Titolo Testata:
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
fascicolo: 3, volume: 11, anno: 2001,
pagine: 198 - 204
SICI:
1048-891X(200105/06)11:3<198:DOH5H7>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYMERASE-CHAIN-REACTION; HUMAN-PAPILLOMAVIRUS INFECTION; CERVICAL INTRAEPITHELIAL NEOPLASIA; CYTOLOGICALLY NORMAL WOMEN; NUCLEOTIDE-SEQUENCE; HIGH-RISK; NATURAL-HISTORY; DNA; CANCER; AMPLIFICATION;
Keywords:
cervical cancer; dysplasia; HPV; oncogenic; prevalence;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Meyer, T Inst Immunol Pathol & Mol Biol, Lademannbogen 61, D-22339 Hamburg, Germany Inst Immunol Pathol & Mol Biol Lademannbogen 61 Hamburg Germany D-22339
Citazione:
T. Meyer et al., "Distribution of HPV 53, HPV 73 and CP8304 in genital epithelial lesions with different grades of dysplasia", INT J GYN C, 11(3), 2001, pp. 198-204

Abstract

To characterize the risk of malignant progression of cervical epithelial lesions associated with human papillomavirus (HPV) types of yet unknown oncogenic potential the prevalences of these HPVs in different cervical epitheilal lesions of 809 patients were determined. HPV types 53, 73, and CP8304 were detected in genital specimens of 16, 22, and 12 of the patients, respectively. The ratio of prevalence in high grade dysplastic lesions or cancersand low grade dysplastic lesions or normal specimens was calculated and compared to corresponding values of well known high-risk (HR) and low-risk (LR) HPVs. For HPV 6, 11, 16, 18, 35, and 73 a ratio of 0.1, 0.2, 5.9, 6.5, 2.5, and 2.4, respectively, was calculated. The ratios of HPV53 and CP8304 were less than 1. Moreover, in contrast to HPV73, these viruses have never been detected in cancer specimens. Thus, HPV53 and CP8304 infections are probably not associated with a high risk of carcinogenesis, while HPV73 could be another HR-HPV type.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 16:27:55