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Titolo:
Measurement of inflammatory mediators of mast cells and eosinophils in native nasal lavage fluid in nasal polyposis
Autore:
Di Lorenzo, G; Drago, A; Pellitteri, ME; Candore, G; Colombo, A; Gervasi, F; Pacor, ML; DAmbrosio, FP; Caruso, C;
Indirizzi:
Univ Palermo, Ist Med Interna & Geriatria, I-90127 Palermo, Italy Univ Palermo Palermo Italy I-90127 a & Geriatria, I-90127 Palermo, Italy Univ Palermo, Dipartimento Biopatol & Metodol Biomed, Lab Immunopatol, I-90127 Palermo, Italy Univ Palermo Palermo Italy I-90127 b Immunopatol, I-90127 Palermo, Italy Civ Cristina Ascoli Palermo, Serv Patol Clin ARNAS, Palermo, Italy Civ Cristina Ascoli Palermo Palermo Italy ol Clin ARNAS, Palermo, Italy Univ Verona, Dipartimento Med Interna & Sperimentale, I-37100 Verona, Italy Univ Verona Verona Italy I-37100 a & Sperimentale, I-37100 Verona, Italy Univ Messina, Scuola Specializzaz Allergol & Immunol Clin, Messina, Italy Univ Messina Messina Italy zzaz Allergol & Immunol Clin, Messina, Italy
Titolo Testata:
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
fascicolo: 2, volume: 125, anno: 2001,
pagine: 164 - 175
SICI:
1018-2438(200106)125:2<164:MOIMOM>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-FACTOR-BETA; SERUM IGE LEVELS; ALLERGIC RHINITIS; POLLEN SEASON; CATIONIC PROTEIN; ASTHMA; MUCOSA; QUANTITATION; LYMPHOCYTES; EXPRESSION;
Keywords:
allergic rhinitis; eosinophils; eosinophil cationic protein; histamine; nasal lavage fluid; nasal polyposis; tryptase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Di Lorenzo, G Univ Palermo, Ist Med Interna & Geriatria, Via Vespro 141, I-90127 Palermo, Italy Univ Palermo Via Vespro 141 Palermo Italy I-90127 mo, Italy
Citazione:
G. Di Lorenzo et al., "Measurement of inflammatory mediators of mast cells and eosinophils in native nasal lavage fluid in nasal polyposis", INT A AL IM, 125(2), 2001, pp. 164-175

Abstract

Background: Nasal polyposis (NP) often coexists with asthma, rhinitis and sinusitis. Polyp histology typically shows chronic, eosinophilic inflammation. The inflammatory cell infiltrate generally includes eosinophils, lymphocytes, plasma cells and mast cells. Objective: To gain insight into the natural history of NP, we analysed mediator levels and leukocyte values in nasal fluids and eosinophil cationic protein (ECP), total IgE levels and eosinophils in the blood in several groups of both allergic and non-allergic patients with nasal polyps and in patients with allergic rhinitis (AR). Methods: Thirty-two patients with nasal polyps entered the study. As a control group, we studied 55 patients with AR, i.e. 20 patients with seasonal AR to grass pollen, 24 with AR sensitive to Parietaria and 11 with AR sensitive tohouse dust mite (HDM). Eighteen patients with nasal polyps were also allergic patients (8 were sensitive to Parietaria and 10 were sensitive to HDM),whereas 14 were non-allergic patients. Tryptase and histamine values were assayed in nasal fluids, whereas total IgE was determined in serum. ECP values were assayed both in nasal fluids and serum. Eosinophils were quantified both in the blood and nasal fluids. Results: Tryptase levels were significantly higher in the nasal lavages from patients with NP than in those frompatients without NP (4.7 vs. 3.5 U/I, p < 0.001) and correlated with symptom scores (r(s) = 0.42, p < 0.0001). The median levels of histamine in nasal fluids from patients with NP were also significantly higher than those observed in patients without NP (50.0 vs. 21.3 ng/ml, p < 0.001), but did notcorrelate with symptom scores. Finally, the median levels of ECP in nasal fluids from patients with NP were significantly higher than those observed in patients without NP (38.1 vs. 16.1 ng/ml, p < 0.001) and correlated withsymptom scores (r(s) = 0.38, p < 0.001). Analysis of variance showed that,among the variables studied, the presence of nasal polyps was the factor responsible for the higher levels of tryptase, histamine and ECP in nasal fluids. With regard to leukocyte counts in nasal fluids, no significant differences were observed between rhinitis patients with NP and those without NP. With regard to serum ECP and serum total IgE, no significant differences were detected between the two groups under study. Blood eosinophil levels in patients with NP were significantly higher than those observed in patients without NP (5.8 vs. 5.6, p = 0.002). Analysis of variance showed that both the presence of nasal polyps and the type of sensitisation were important. Considering the total symptom scores, no significant differences were observed between rhinitis patients with NP and those without NP. Conclusions: The present findings are consistent with the view that chronic eosinophil mucosal inflammatory disease in NP involves a self-sustaining mechanism, i.e. local release of inflammatory mediators, independent of allergen stimulation of nasal mucosa. Increased release of inflammatory mediators contributes to the development of nasal polyps, determining oedema and an increased recruitment of inflammatory cells. Besides eosinophils, mast cells also playa key role in this process. Copyright (C) 2001 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 05:58:58