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Titolo:
Can immunoregulatory lactic acid bacteria be used as dietary supplements to limit allergies?
Autore:
Cross, ML; Gill, HS;
Indirizzi:
Massey Univ, Inst Food Nutr & Human Hlth, Milk & Hlth Res Ctr, Palmerston North, New Zealand Massey Univ Palmerston North New Zealand Palmerston North, New Zealand
Titolo Testata:
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
fascicolo: 2, volume: 125, anno: 2001,
pagine: 112 - 119
SICI:
1018-2438(200106)125:2<112:CILABB>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; CHRONIC YOGURT CONSUMPTION; GRAM-POSITIVE BACTERIA; CASEI STRAIN SHIROTA; GG-DERIVED ENZYMES; CYTOKINE PRODUCTION; IMMUNE-SYSTEM; PROBIOTIC BACTERIA; IGE PRODUCTION; IFN-GAMMA;
Keywords:
dietary supplements; allergy; intestinal microflora; lactic acid bacteria; immunoregulation; interferon; interleukin-12;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
75
Recensione:
Indirizzi per estratti:
Indirizzo: Cross, ML Massey Univ, Inst Food Nutr & Human Hlth, Milk & Hlth Res Ctr, Palmerston North, New Zealand Massey Univ Palmerston North New Zealand n North, New Zealand
Citazione:
M.L. Cross e H.S. Gill, "Can immunoregulatory lactic acid bacteria be used as dietary supplements to limit allergies?", INT A AL IM, 125(2), 2001, pp. 112-119

Abstract

Studies in gnotobiotic animals have suggested that the intestinal bacterial flora may play an important role in priming the immune system during ontogeny to limit dysfunctional responses, including allergy. Prospective clinical studies have identified a higher incidence of allergy expression in early childhood among children who have low enteric populations of lactic acidbacteria (LAB), such as lactobacilli and bifidobacteria, further supporting a role for gut-colonizing bacteria in regulating immunological atopy. There is some evidence to suggest that supplementing the human diet with probiotic LAB might combat both allergy development and expression of atopy in allergy sufferers; however, definitive information, in the form of controlled intervention trials, remains scant. Recent immunological evidence has indicated that certain strains of LAB can stimulate the production of type I and II interferons and pro-interferon monokines (IL-12 and IL-18), followingcontact with the immune system; therefore, probiotic forms of immunoregulatory LAB could be used as dietary supplements to modify the gut microflora and provide pro-T helper cell 1 (Th1) STAT-activating signals sufficient todeviate the immune phenotype and correct the Th2-type bias which promotes allergy. This review outlines the clinical and laboratory evidence of a role for LAB in combating allergies, and attempts to explain this phenomenon in terms of our current understanding of immunoregulatory signals produced by gut-colonizing microbes. Copyright (C) 2001 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 17:55:31