Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Plasma amino-terminal pro-brain natriuretic peptide levels in subjects presenting to the Emergency Department with suspected acute coronary syndrome:possible role in selecting patients for follow up?
Autore:
Campbell, DJ; Munir, V; Hennessy, OF; Dent, AW;
Indirizzi:
St Vincents Hosp, Emergency Dept, Melbourne, Vic, Australia St Vincents Hosp Melbourne Vic Australia Dept, Melbourne, Vic, Australia St Vincents Hosp, Dept Med Imaging, Melbourne, Vic, Australia St Vincents Hosp Melbourne Vic Australia ging, Melbourne, Vic, Australia St Vincents Inst Med Res, Melbourne, Vic, Australia St Vincents Inst Med Res Melbourne Vic Australia lbourne, Vic, Australia
Titolo Testata:
INTERNAL MEDICINE JOURNAL
fascicolo: 4, volume: 31, anno: 2001,
pagine: 211 - 219
SICI:
1444-0903(200105/06)31:4<211:PAPNPL>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
VENTRICULAR SYSTOLIC DYSFUNCTION; ACUTE MYOCARDIAL-INFARCTION; CONGESTIVE-HEART-FAILURE; CLINICAL CHARACTERISTICS; PRIMARY-CARE; PREVALENCE; MARKER; ANGIOPLASTY; IMPAIRMENT; POPULATION;
Keywords:
acute coronary syndrome; BNP; heart failure; natriuretic peptide;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Campbell, DJ St Vincents Inst Med Res, 41 Victoria Parade, Fitzroy, Vic 3065, Australia St Vincents Inst Med Res 41 Victoria Parade Fitzroy Vic Australia 3065
Citazione:
D.J. Campbell et al., "Plasma amino-terminal pro-brain natriuretic peptide levels in subjects presenting to the Emergency Department with suspected acute coronary syndrome:possible role in selecting patients for follow up?", INTERN M J, 31(4), 2001, pp. 211-219

Abstract

Background: Plasma amino-terminal pro-brain natriuretic peptide (NT-proBNP) level is a sensitive and specific indicator of cardiac dysfunction. Aim: To determine whether plasma NT-proBNP level is elevated at the time of presentation with acute coronary syndrome (ACS) and whether it may assistin the diagnosis of heart failure and myocardial ischaemia in the Emergency Department. Methods: Plasma NT-proBNP levels were measured prospectively in 201 unselected presentations to the Emergency Department with suspected ACS where cardiac injury markers were requested by clinicians as part of routine assessment. NT-proBNP levels were correlated with clinical, electrocardiogram (ECG), biochemical and radiological findings. Results: Elevated NT-proBNP level detected heart failure with high sensitivity (95-96%). Among patients without heart failure, NT-proBNP levels were increased more frequently in patients with previously diagnosed ischaemic heart disease. Elevated NT-proBNP level predicted cardiomegaly and a cardiaccause of presentation. However, the NT-proBNP level was not associated with ECG or biochemical markers of myocardial ischaemia, and only one-third ofpatients with ACS showed an increase of 30% or more in NT-proBNP level at repeat measurement of cardiac injury markers 5 h after presentationConclusions: Although elevated NT-proBNP level detected heart failure withhigh sensitivity, NT-proBNP level did not assist in the diagnosis of acutemyocardial ischaemia. These findings indicate that the major determinant of elevated NT-proBNP level on presentation with suspected ACS was underlying cardiac dysfunction rather than acute myocardial ischaemia. This suggeststhat NT-proBNP measurement in patients with a suspected cardiac reason forpresentation to the Emergency Department may identify a previously unrecognized group of patients without acute ischaemia who may nevertheless benefit from further investigation of cardiac function.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 14:26:17