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Titolo:
Myasthenia gravis with thymoma is more common in the Maori and Pacific Island populations in New Zealand
Autore:
Fink, JN; Wallis, WE; Haydock, DA;
Indirizzi:
Auckland Hosp, Dept Neurol, Auckland, New Zealand Auckland Hosp AucklandNew Zealand , Dept Neurol, Auckland, New Zealand Greenlane Hosp, Dept Cardiothorac Surg, Auckland, New Zealand Greenlane Hosp Auckland New Zealand othorac Surg, Auckland, New Zealand
Titolo Testata:
INTERNAL MEDICINE JOURNAL
fascicolo: 4, volume: 31, anno: 2001,
pagine: 206 - 210
SICI:
1444-0903(200105/06)31:4<206:MGWTIM>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
THYMIC EPITHELIAL TUMORS; HONG-KONG CHINESE; FOLLOW-UP; ONSET; THYMECTOMY; DISEASE; PATHOGENESIS; EPIDEMIOLOGY; ASSOCIATION; EXPRESSION;
Keywords:
Maori; myasthenia gravis; Polynesian; thymoma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Fink, JN Beth Israel Deaconess Med Ctr, Stroke Div, Dana 710,330 BrooklineAve, Boston, MA 02215 USA Beth Israel Deaconess Med Ctr Dana 710,330 Brookline Ave Boston MA USA 02215
Citazione:
J.N. Fink et al., "Myasthenia gravis with thymoma is more common in the Maori and Pacific Island populations in New Zealand", INTERN M J, 31(4), 2001, pp. 206-210

Abstract

Background: The association of myasthenia gravis (MG) with thymoma is wellrecognized. Our clinical impression has been that MG associated with thymoma may be more common in patients of Polynesian descent than in other races. Aim: To determine the influence of ethnicity on the association of MG withthymoma in our population. Method: Review of all cases of thymectomy performed at Greenlane Hospital in Auckland for the 20-year period from June 1978 to June 1998. Results: There were 103 thymectomies performed in the study period. Fifty-five thymomas were identified, 15 in subjects of Maori or Pacific Island ethnicity and 40 in subjects of other races, predominantly Caucasian. Ten of 15 Maori or Pacific Island subjects with thymoma had MG (67%), compared with 15 of 40 subjects of other races (37.5%, P = 0.05). The mean age of Maorior Pacific Island subjects with thymoma and MG was 42.5 years, compared with 56.3 years in subjects from other races (P = 0.06). All five Maori and Pacific Island subjects with invasive thymoma had MG, whereas only four of 15 subjects (27%) from other races with invasive rumours had MG (P < 0.01). The overall incidence of thymoma and the proportion of thymomas that were invasive did not differ between the ethnic groups. Conclusions: Myasthenia gravis with thymoma occurs more frequently among Maori or Pacific Island people than in other racial groups in our population. This is due to an increase in the proportion of cases with thymoma who have MG in this group, while the overall frequency of cases of thymoma is similar between groups. MG with thymoma in the Maori or Pacific Island populations also presents at a younger age and is more often associated with tumour invasion.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/10/20 alle ore 14:46:20