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Titolo:
Ketamine and midazolam kinetics during continuous hemodiafiltration in patients with multiple organ dysfunction syndrome
Autore:
Tsubo, T; Sakai, I; Okawa, H; Ishihara, H; Matsuki, A;
Indirizzi:
Hirosaki Univ, Sch Med, Intens Care Unit, Hirosaki, Aomori 036, Japan Hirosaki Univ Hirosaki Aomori Japan 036 Unit, Hirosaki, Aomori 036, Japan Hirosaki Univ, Sch Med, Dept Anesthesiol, Hirosaki, Aomori 036, Japan Hirosaki Univ Hirosaki Aomori Japan 036 siol, Hirosaki, Aomori 036, Japan
Titolo Testata:
INTENSIVE CARE MEDICINE
fascicolo: 6, volume: 27, anno: 2001,
pagine: 1087 - 1090
SICI:
0342-4642(200106)27:6<1087:KAMKDC>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
RENAL REPLACEMENT THERAPIES; PHARMACOKINETICS; SEDATION; FAILURE;
Keywords:
ketamine; midazolam; CHDF;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Tsubo, T Hirosaki Univ, Sch Med, Intens Care Unit, Honcyo 53, Hirosaki, Aomori 036,Japan Hirosaki Univ Honcyo 53 Hirosaki Aomori Japan 036 omori 036,Japan
Citazione:
T. Tsubo et al., "Ketamine and midazolam kinetics during continuous hemodiafiltration in patients with multiple organ dysfunction syndrome", INTEN CAR M, 27(6), 2001, pp. 1087-1090

Abstract

Objective: To assess the effect of continuous hemodiafiltration (CHDF) on ketamine and midazolam kinetics in multiple organ dysfunction syndrome (MODS). Design and setting: Consecutive clinical study in a general intensive careunit of a university hospital. Patients: Twelve adult patients with MODS requiring CHDF. Measurements and results: A total of 68 samples were collected during CHDFfor ketamine, norketamine, and midazolam assays. The clearance values for ketamine and norketamine were 10.8 +/- 6.6 and 10.9 +/- 11.5 ml/min and their daily extractions were 21.4 +/- 7.1 and 10.2 +/- 11.5 mg/day, respectively. Midazolam was not eliminated through the filter during CHDF. There wereno changes in Ramsay Sedation Score or Glasgow Coma Scale during CHDF. Conclusions: Small fractions of ketamine and norketamine were eliminated during CHDF in MODS. Midazolam was not eliminated during CHDF. CHDF did not affect the sedation using ketamine and midazolam even in MODS patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 09:06:14