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Titolo:
Efficacy of thrombolysis in patients with acute myocardial infarction requiring cardiopulmonary resuscitation
Autore:
Ruiz-Bailen, M; de Hoyos, EA; Serrano-Corcoles, MC; Diaz-Castellanos, MA; Ramos-Cuadra, JA; Reina-Toral, A;
Indirizzi:
Hosp Poniente, Crit Care & Emergencies Dept, Intens Care Unit, El Ejido 04700, Almeria, Spain Hosp Poniente El Ejido Almeria Spain 04700 El Ejido 04700, Almeria, Spain Hosp Univ Virgen Nieves, Crit Care & Emergencies Dept, Intens Care Unit, Granada, Spain Hosp Univ Virgen Nieves Granada Spain Intens Care Unit, Granada, Spain
Titolo Testata:
INTENSIVE CARE MEDICINE
fascicolo: 6, volume: 27, anno: 2001,
pagine: 1050 - 1057
SICI:
0342-4642(200106)27:6<1050:EOTIPW>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADVANCED LIFE-SUPPORT; PLASMINOGEN-ACTIVATOR; CARDIOGENIC-SHOCK; GUIDELINES; THERAPY; ASSOCIATION; REPERFUSION; MANAGEMENT; COMMITTEE; SAFETY;
Keywords:
acute myocardial infarction; cardiac arrest; cardiopulmonary resuscitation; mortality; complications; thrombolysis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Ruiz-Bailen, M Hosp Poniente, Crit Care & Emergencies Dept, Intens Care Unit, El Ejido 04700, Almeria, Spain Hosp Poniente El Ejido Almeria Spain 04700 Almeria, Spain
Citazione:
M. Ruiz-Bailen et al., "Efficacy of thrombolysis in patients with acute myocardial infarction requiring cardiopulmonary resuscitation", INTEN CAR M, 27(6), 2001, pp. 1050-1057

Abstract

Objective: To evaluate the efficacy and safety of systemic thrombolysis administered to resuscitated patients after cardiac arrest (CA) due to an acute myocardial infarction (AMI), through a study of their mortality and haemorrhagic complications. Design: We studied a. retrospective cohort of patients with ischaemic heart disease gathered from the database of the Spanish multi-centre project "Analysis of Delay in AMI" (ARIAM). Setting: Intensive care (ICU) and coronary care (CCU) units of 77 Spanish hospitals. Patients and participants: The study period was from 1 January 1995 to 1 January 2000, when 22,922 patients were included in the ARIAM database register; 13,704 were diagnosed with AMI and we studied 303 of these AMI patients admitted after resuscitation for CA. Measurements and results: Of the 303 patients studied, 228 were male (75.25%); the mean age was 64.57 +/- 12.48 years. Systemic thrombolysis was administered to 67 patients (group I) and the remaining 236 patients were managed without this treatment (group II). The ICU/CCU mortality rate of the series was 39.93% (121 patients); that of group I was 17.91% (12 patients) andthat of group II 46.18% (209 patients) (P < 0.00001)., Group I required less mechanical ventilation (group I, 42.85% vs group II, 80.76%; P < 0.00001) and fewer cardiopulmonary resuscitation attempts (33.34% vs 60.98%, P < 0.0001). Group I also showed a lower incidence of cardiogenic shock (14.28% vs 39.01%, P < 0.0001) and anoxic encephalopathy (8.62% us 39.89% P = 0.006). There were no fatal haemorrhagic complications in either group. Logisticregression analysis showed the administration of thrombolysis to be an independent variable that protected against mortality,Conclusions: The administration of thrombolysis to patients with AMI who require resuscitation may be efficacious in reducing mortality and is safe, with no increase in haemorrhagic complications.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 07:02:26