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Titolo:
First-trimester screening for trisomy 21 in singleton pregnancies achievedby assisted reproduction
Autore:
Liao, AW; Heath, V; Kametas, N; Spencer, K; Nicolaides, KH;
Indirizzi:
Univ London Kings Coll Hosp, Harris Birthright Res Ctr Fetal Med, Sch Med,London SE5 9RS, England Univ London Kings Coll Hosp London England SE5 9RS ndon SE5 9RS, England Harold Wood Hosp, Dept Clin Biochem, Endocrine Unit, Romford, Essex, England Harold Wood Hosp Romford Essex England ine Unit, Romford, Essex, England
Titolo Testata:
HUMAN REPRODUCTION
fascicolo: 7, volume: 16, anno: 2001,
pagine: 1501 - 1504
SICI:
0268-1161(200107)16:7<1501:FSFT2I>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
IN-VITRO FERTILIZATION; HUMAN CHORIONIC-GONADOTROPIN; FETAL NUCHAL TRANSLUCENCY; DOWNS-SYNDROME; SERUM; MARKERS; GESTATION; RISK;
Keywords:
free beta-HCG; nuchal translucency; PAPP-A; screening; trisomy 21;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Nicolaides, KH Univ London Kings Coll Hosp, Harris Birthright Res Ctr Fetal Med, Sch Med,Denmark Hill, London SE5 9RS, England Univ London Kings CollHosp Denmark Hill London England SE5 9RS
Citazione:
A.W. Liao et al., "First-trimester screening for trisomy 21 in singleton pregnancies achievedby assisted reproduction", HUM REPR, 16(7), 2001, pp. 1501-1504

Abstract

BACKGROUND: The possible effect of assisted reproduction on first-trimester screening for trisomy 21 was examined by fetal nuchal translucency thickness (NT), maternal serum free beta -human chorionic gonadotrophin (HCG) andpregnancy-associated plasma protein-A (PAPP-A), METHODS: Parameters were measured at 11-14 weeks in 411 singleton pregnancies achieved by controlled ovarian stimulation, including 220 that had undergone IVF, Results were compared with 1233 singleton pregnancies conceived spontaneously. RESULTS: In the IVF pregnancies, the median fetal NT was not significantly different from that in controls, whilst the median free beta -HCG was significantly increased, and PAPP-A was significantly decreased. In the intracytoplasmic sperm injection group, fetal NT and free beta -HCG values were not significantly different from those in controls, but PAPP-A was significantly decreased. In those pregnancies achieved by ovarian stimulation, neither fetal NT, free beta -HCG nor PAPP-A were significantly different from the control group. CONCLUSIONS: In IVF pregnancies, screening for trisomy 21 by fetal NT, maternal serum free beta -HCG and PARE-A levels may be associated with a 1.2% higher false-positive rate than in natural conception.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 02:12:48