Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Leptin concentrations in hirsute women with polycystic ovary syndrome or idiopathic hirsutism: influence on LH and relationship with hormonal, metabolic, and anthropometric measurements
Autore:
Spritzer, PM; Poy, M; Wiltgen, D; Mylius, LS; Capp, E;
Indirizzi:
Univ Fed Rio Grande Sul, Hosp Clin Porto Alegre, Gynecol Endocrinol Unit, Div Endocrinol, BR-90050170 Porto Alegre, RS, Brazil Univ Fed Rio Grande Sul Porto Alegre RS Brazil BR-90050170 BC, RS, Brazil Univ Fed Rio Grande Sul, Dept Physiol, BR-90050170 Porto Alegre, RS, Brazil Univ Fed Rio Grande Sul Porto Alegre RS Brazil BR-90050170 BC, RS, Brazil Univ Fed Rio Grande Sul, Dept Obstet & Gynecol, BR-90050170 Porto Alegre, RS, Brazil Univ Fed Rio Grande Sul Porto Alegre RS Brazil BR-90050170 BC, RS, Brazil
Titolo Testata:
HUMAN REPRODUCTION
fascicolo: 7, volume: 16, anno: 2001,
pagine: 1340 - 1346
SICI:
0268-1161(200107)16:7<1340:LCIHWW>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
INAPPROPRIATE GONADOTROPIN-SECRETION; IMPAIRED GLUCOSE-TOLERANCE; LUTEINIZING-HORMONE; INSULIN-RESISTANCE; CIRCULATING LEPTIN; FASTING GLUCOSE; BODY-WEIGHT; OBESE GENE; SERUM; DISEASE;
Keywords:
idiopathic hirsutism; insulin resistance; leptin; LH; polycystic ovary syndrome;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Spritzer, PM Univ Fed Rio Grande Sul, Inst Ciencias Basicas Saude, Dept Fisiol, Rua Sarmento Leite 500, BR-90170050 Porto Alegre, RS, Brazil Univ FedRio Grande Sul Rua Sarmento Leite 500 Porto Alegre RS Brazil BR-90170050 BC
Citazione:
P.M. Spritzer et al., "Leptin concentrations in hirsute women with polycystic ovary syndrome or idiopathic hirsutism: influence on LH and relationship with hormonal, metabolic, and anthropometric measurements", HUM REPR, 16(7), 2001, pp. 1340-1346

Abstract

BACKGROUND: The known association between leptin, obesity and insulin action suggests that leptin may have a role in polycystic ovarian syndrome (PCOS) but this has only been addressed peripherally. METHODS: We assessed the influence of leptin on LH and investigated the relationship between leptin and body mass index (BMI), waist:hip ratio (WHR), androgen concentrations, fasting insulin and insulin:glucose ratio (IGR) in 27 women with PCOS and in 20 age- and weight-matched women with regular, ovulatory menstrual cyclesand idiopathic hirsutism (IH), RESULTS: Leptin concentrations were significantly higher in obese PCOS women than in normal weight women with either PCOS or IH (P = 0.0028), but did not differ between obese women with PCOS and IH, WHR, insulin: concentrations and IGR were significantly higher in obese PCOS patients in comparison with the three other groups. In IH patients,the association between leptin concentrations and WHR was lost after adjustment for BMI, In PCOS patients, a significant correlation was observed between leptin and fasting insulin concentrations, IGR, WHR and LH. After adjustment for BMI, only the correlation with LH remained significant. A stepwise regression model was set up with LH as the dependent variable to test the hypothesis that the concentrations of leptin might be modulating the concentrations of LH in PCOS patients, The relationship of LH concentrations with IGR was found to be BMI dependent. In contrast, leptin concentrations contributed negatively and significantly to LH concentrations, independently of either BMI or IGR, CONCLUSIONS: We speculate that the known attenuation in basal or stimulated response of LH in obese PCOS patients might be related to leptin resistance, which could influence LH hypersecretion, In IH ovulatory patients, normal LH concentrations suggest the presence of preservedregulatory mechanisms of GnRH pulsatility, Further studies are needed to specifically investigate the proposed correlation between leptin and GnRH modulation in PCOS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 06:52:04