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Titolo:
Fluvoxamine is ineffective in the treatment of enuresis in children and adolescents: an open-label pilot study
Autore:
Toren, P; Eldar, S; Laor, N; Wolmer, L; Samuel, E; Weizman, R;
Indirizzi:
Tel Aviv Univ, Sch Med, Tel Aviv Community Mental Hlth Ctr, IL-67197 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-67197 th Ctr, IL-67197 Tel Aviv, Israel Tel Aviv Univ, Sackler Sch Med, IL-69978 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-69978 ch Med, IL-69978 Tel Aviv, Israel Yale Univ, Sch Med, Yale Child Study Ctr, New Haven, CT USA Yale Univ NewHaven CT USA Med, Yale Child Study Ctr, New Haven, CT USA
Titolo Testata:
HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL
fascicolo: 4, volume: 16, anno: 2001,
pagine: 327 - 332
SICI:
0885-6222(200106)16:4<327:FIIITT>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
NOCTURNAL ENURESIS; URINARY-BLADDER; ANTIDEPRESSANT; CLOZAPINE; SCHIZOPHRENIA; FLUOXETINE; RECEPTORS;
Keywords:
enuresis; serotonin; fluvoxamine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Toren, P Tel Aviv Univ, Sch Med, Tel Aviv Community Mental Hlth Ctr, 9 Hatzvi St,Ramat Hatayassim, IL-67197 Tel Aviv, Israel Tel Aviv Univ 9 Hatzvi St,Ramat Hatayassim Tel Aviv Israel IL-67197
Citazione:
P. Toren et al., "Fluvoxamine is ineffective in the treatment of enuresis in children and adolescents: an open-label pilot study", HUM PSYCHOP, 16(4), 2001, pp. 327-332

Abstract

Tricyclic antidepressants possess established antienuretic properties. Theselective serotonin reuptake inhibitors (SSRIs) have similar antidepressant properties to the tricyclic antidepressants and a safer side effect profile. The aim of the present study was to evaluate the antienuretic efficacy of one SSRI, fluvoxamine. Nine children aged 9 to 14 years with primary enuresis which was resistant to behavioral therapy participated in the study. All received fluvoxamine, 75-100 mg per day. In four, the enuresis was the only focus of clinical attention, and five received fluvoxamine for other primary indications. Enuresis was monitored daily, and mean voiding frequency was compared between three phases: baseline, on treatment and off treatment. Fluvoxamine had no statistically significant effect on enuresis. Fluvoxamine does not seem to possess significant antienuretic properties. We suggest that the combination of serotonergic with anticholinergic activity is amajor factor in the antienuretic activity. In the treatment of children oradolescents with obsessive-compulsive disorder and comorbid enuresis, clomipramine may be preferred over SSRIs. Copyright (C) 2001 John Wiley & Sons,Ltd.

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Documento generato il 04/04/20 alle ore 14:31:57