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Titolo:
Influence of cigarette smoking on prepulse inhibition of the acoustic startle response in schizophrenia
Autore:
Kumari, V; Soni, W; Sharma, T;
Indirizzi:
Inst Psychiat, Dept Psychiat, Div Psychol Med, Sect Cognit Psychopharmacol, London SE5 8AF, England Inst Psychiat London England SE5 8AF opharmacol, London SE5 8AF, England
Titolo Testata:
HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL
fascicolo: 4, volume: 16, anno: 2001,
pagine: 321 - 326
SICI:
0885-6222(200106)16:4<321:IOCSOP>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE SUBCUTANEOUS NICOTINE; SENSORY INHIBITION; ANIMAL-MODELS; REFLEX; NORMALIZATION; STIMULATION; ATTENTION; SMOKERS; MEMORY; RATS;
Keywords:
acoustic startle reflex; prepulse inhibition; schizophrenia; sensorimotor gating; startle gating; tobacco smoking;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Sharma, T Inst Psychiat, Dept Psychiat, Div Psychol Med, Sect Cognit Psychopharmacol, De Crespigny Pk, London SE5 8AF, England Inst Psychiat De Crespigny Pk London England SE5 8AF F, England
Citazione:
V. Kumari et al., "Influence of cigarette smoking on prepulse inhibition of the acoustic startle response in schizophrenia", HUM PSYCHOP, 16(4), 2001, pp. 321-326

Abstract

The prevalence of tobacco smoking is known to be higher in patients with schizophrenia than other psychiatric disorders and general population. Thesepatients also show reduced prepulse inhibition (PPI) of the startle response. PPI refers to a reduction in response to a strong startling stimulus ifpreceded shortly by a stimulus of sub-threshold intensity. PPI is thought of as an objective index of sensorimotor gating. Nicotine administered subcutaneously or via cigarette smoking enhances PPI in healthy human beings. It also enhances PPI at low, but not high, doses in the rat. We examined theinfluence of smoking on PPI of the acoustic startle response in 46 male patients with chronic schizophrenia. In a naturalistic design, patients (n = 9) who smoked a cigarette less than 10 min prior to being tested on PPI were compared with other smoking (n = 23) and nonsmoking patients (n = 14). Wefound that the group of patients who smoked a cigarette prior to being tested had significantly greater PPI than other two groups. These observationssuggest a PPI-enhancing effect of cigarette smoking on PPI in patents withschizophrenia. Higher prevalence of cigarette smoking in schizophrenic patients may reflect an attempt to improve sensorimotor gating deficits. Copyright (C) 2001 John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 15:59:27