Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Metabolic syndromes in human immunodeficiency virus infection
Autore:
Macallan, DC;
Indirizzi:
St Georges Hosp, Sch Med, Dept Infect Dis, London SW17 0RE, England St Georges Hosp London England SW17 0RE ct Dis, London SW17 0RE, England
Titolo Testata:
HORMONE RESEARCH
, volume: 55, anno: 2001, supplemento:, 1
pagine: 36 - 41
SICI:
0301-0163(2001)55:<36:MSIHIV>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN GROWTH-HORMONE; PLACEBO-CONTROLLED TRIAL; ENERGY-EXPENDITURE; FAT DISTRIBUTION; HIV-INFECTION; THERAPY; AIDS; HYPERTRIGLYCERIDEMIA; DETERMINANTS; TUBERCULOSIS;
Keywords:
HIV; AIDS; metabolism; nutrition; wasting; lipodystrophy; growth hormone;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Macallan, DC St Georges Hosp, Sch Med, Dept Infect Dis, Cranmer Terrace, London SW17 0RE, England St Georges Hosp Cranmer Terrace London England SW17 0RE land
Citazione:
D.C. Macallan, "Metabolic syndromes in human immunodeficiency virus infection", HORMONE RES, 55, 2001, pp. 36-41

Abstract

Infection with human immunodeficiency virus (HIV) is associated with marked disturbance of metabolism affecting the metabolism of carbohydrates, fatsand proteins. In the first decade of clinical experience of HIV, the primary clinical manifestation of such disturbed metabolism was wasting. Such wasting was often severe and contributed significantly to the morbidity and mortality of AIDS. Mechanistic studies demonstrated that in addition to the effects of altered intermediary metabolism, reduced food intake played a major role in the causation of AIDS-related wasting. More recently, potent anti-retroviral drugs have dramatically changed the clinical consequences of HIV infection. Wasting has become far less frequent among infected patientsand occurs in only a small percentage of subjects on effective anti-retroviral therapy. However, a new constellation of metabolic syndromes has become apparent characterized by altered body fat distribution ('lipodystrophy'), lactic acidosis and evidence of mitochondrial dysfunction, The mechanistic basis for such syndromes is currently unclear, but is the subject of ongoing research. Copyright (C) 2001 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 13:00:47