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Titolo:
Possible roles of insulin-like growth factor in regulation of physiological and pathophysiological liver growth
Autore:
Skrtic, S; Wallenius, K; Sjogren, K; Isaksson, OGP; Ohlsson, C; Jansson, JO;
Indirizzi:
Sahlgrens Univ Hosp, Div Endocrine, RCEM, SE-41345 Gothenburg, Sweden Sahlgrens Univ Hosp Gothenburg Sweden SE-41345 -41345 Gothenburg, Sweden
Titolo Testata:
HORMONE RESEARCH
, volume: 55, anno: 2001, supplemento:, 1
pagine: 1 - 6
SICI:
0301-0163(2001)55:<1:PROIGF>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEPATIC STELLATE CELLS; SINUSOIDAL ENDOTHELIAL-CELLS; FAT-STORING CELLS; FACTOR-I; RAT-LIVER; DNA-SYNTHESIS; PHOSPHATIDYLINOSITOL 3-KINASE; HYPOPHYSECTOMIZED RATS; CARBON-TETRACHLORIDE; BINDING-PROTEINS;
Keywords:
IGF; HGF; liver; growth; paracrine; gene knock-out;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Jansson, JO Sahlgrens Univ Hosp, Div Endocrine, RCEM, Grona Straket 8, SE-41345 Gothenburg, Sweden Sahlgrens Univ Hosp Grona Straket 8 Gothenburg Sweden SE-41345
Citazione:
S. Skrtic et al., "Possible roles of insulin-like growth factor in regulation of physiological and pathophysiological liver growth", HORMONE RES, 55, 2001, pp. 1-6

Abstract

Background/Aims: Almost all circulating insulin-like growth factor-1 (IGF-1) is produced and secreted from the liver. However, the possible role of IGF-1 in local regulation of liver functions including liver growth is unclear. in the present study, we investigated the role of IGF-1 on liver growthin vivo and in hepatic stellate cell function in vitro. Results: Liver-specific knock-out of the IGF-1 gene by use of the cre-loxP system caused enhanced liver growth, possibly reflecting increased growth hormone (GH) secretion due to decreased negative feedback by IGF-1. Studies on cultured rat hepatic stellate cells (HSC) showed that IGF-1 and hepatocyte-conditioned medium (PCcM) time- and dose-dependently increased hepatocyte growth factor (HGF) mRNA and HGF immunoreactivity. IGF-1 and PCcM also enhanced DNA synthesis in the HSC cultures. The PCcM did not contain bioactive IGF-1 and was also able to stimulate proliferation when prepared under serum- and hormone-free conditions, Conclusion: In vivo results show that IGF-1 is not essential for normal growth of the intact liver. The in vitro results indicate thatboth IGF-1 and IGF-1-independent factor(s) from hepatocytes can stimulate HGF production by HSC. It remains to be investigated whether these effects are of importance for liver regeneration or pathological conditions. Copyright (C) 2001 S. Karger AG,Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/06/20 alle ore 02:29:13