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Titolo:
Chronic psychosocial stress regulates the expression of both GR and MR mRNA in the hippocampal formation of tree shrews
Autore:
Meyer, U; van Kampen, M; Isovich, E; Flugge, G; Fuchs, E;
Indirizzi:
German Primate Ctr, Div Neurobiol, D-37077 Gottingen, Germany German Primate Ctr Gottingen Germany D-37077 D-37077 Gottingen, Germany
Titolo Testata:
HIPPOCAMPUS
fascicolo: 3, volume: 11, anno: 2001,
pagine: 329 - 336
SICI:
1050-9631(2001)11:3<329:CPSRTE>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOSTEROID RECEPTOR BALANCE; MESSENGER-RIBONUCLEIC-ACID; CENTRAL-NERVOUS-SYSTEM; MINERALOCORTICOID RECEPTOR; GLUCOCORTICOID RECEPTOR; TUPAIA-BELANGERI; RAT HIPPOCAMPUS; FUNCTIONAL-DIFFERENTIATION; GENE-EXPRESSION; SOCIAL STRESS;
Keywords:
glucocorticoid receptor; mineralocorticoid receptor; hypothalamic-pituitary-adrenal axis; hippocampus; depression;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Meyer, U German Primate Ctr, Div Neurobiol, Kellnerweg 4, D-37077 Gottingen, Germany German Primate Ctr Kellnerweg 4 Gottingen Germany D-37077 ermany
Citazione:
U. Meyer et al., "Chronic psychosocial stress regulates the expression of both GR and MR mRNA in the hippocampal formation of tree shrews", HIPPOCAMPUS, 11(3), 2001, pp. 329-336

Abstract

A persistent hyperactivity of the hypothalamic-pituitary-adrenal axis and thus elevated glucocorticoid levels are main neuroendocrine features of depressive symptomatology in humans. The broad range of effects that are set off by glucocorticoids is mediated by glucocorticoid receptors (GRs) and mineralocorticoid receptors (MRs), which themselves are subject to autoregulation. In order to investigate the impact of longlasting psychological stresson corticosteroid receptor mRNA expression in the hippocampal formation, we employed the psychosocial stress paradigm in male tree shrews (Tupaia belangeri). By in situ hybridization studies and semiquantitative evaluation of stress-induced changes of GR and MR mRNA expression at the single-cell level, brain tissue from subordinate animals which were exposed to 27 days (1h/day) of social confrontation was compared to that of nonstressed animals. Four weeks of stress exposure resulted in a downregulation of CR mRNA in the dentate gyrus and hippocampal subfields CA1 and CA3 of subordinate maletree shrews compared to controls. The MR mRNA content in these subfields of the anterior hippocampus was also clearly reduced. On the contrary, in a more posterior location on the longitudinal axis of the tree shrew hippocampus, the MR message was increased in subfields CA1 and CA3 and in the dentate gyrus. These results suggest a relevance of the stress-induced regulation of both corticosteroid receptor subtype mRNAs in a naturalistic challenging situation. Moreover, the differential regulation of MR mRNA along the rostrocaudal axis of the hippocampus adds another feature to the heterogenouscomposition of this structure. Hippocampus 2001;11:329-336. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 00:50:15