Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
beta-adrenergic blockade in the dentate gyrus in vivo prevents high frequency-induced long-term potentiation of EPSP slope, but not long-term potentiation of population spike amplitude
Autore:
Munro, CAM; Walling, SG; Evans, JH; Harley, CW;
Indirizzi:
Mem Univ Newfoundland, Dept Psychol, St Johns, NF A1B 3X9, Canada Mem UnivNewfoundland St Johns NF Canada A1B 3X9 ohns, NF A1B 3X9, Canada
Titolo Testata:
HIPPOCAMPUS
fascicolo: 3, volume: 11, anno: 2001,
pagine: 322 - 328
SICI:
1050-9631(2001)11:3<322:BBITDG>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOCUS-COERULEUS; PERFORANT PATH; LASTING POTENTIATION; PARAGIGANTOCELLULARIS STIMULATION; AWAKE RAT; NOREPINEPHRINE; ACTIVATION; LTP; INHIBITION; DEPLETION;
Keywords:
timolol; hippocampus; paragigantocellularis nucleus; norepinephrine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Harley, CW Mem Univ Newfoundland, Dept Psychol, St Johns, NF A1B 3X9, Canada Mem Univ Newfoundland St Johns NF Canada A1B 3X9 B 3X9, Canada
Citazione:
C.A.M. Munro et al., "beta-adrenergic blockade in the dentate gyrus in vivo prevents high frequency-induced long-term potentiation of EPSP slope, but not long-term potentiation of population spike amplitude", HIPPOCAMPUS, 11(3), 2001, pp. 322-328

Abstract

High frequency (HF)-induced and norepinephrine (NE)induced long-term potentiation have been hypothesized to utilize common mechanisms of induction and expression in the dentate gyrus. In vitro data tend to support this hypothesis, but few studies have been done in vivo. The present study records perforant path-evoked potentials simultaneously on two micropipettes, one filled with saline and the other with the beta -antagonist, timolol. Stimulation of the paragigantocellularis nucleus (PGI) was used as a method of producing NE release in the dentate gyrus, and thus, to assess the efficacy of beta -receptor blockade on the timolol pipette. beta -blockade by timolol attenuated PGi-induced spike potentiation. HE-induced potentiation of the excitatory post-synaptic potential (EPSP) slope was also blocked by timolol, but HE-induced spike amplitude potentiation was unaffected. These results are consistent with an earlier report examining HE-long-term potentiation (LTP) following 6-OHDA-induced NE depletion, which showed that the EPSP slope LTP depended, for its full expression, on NE, but potentiation of the population spike amplitude component of HE-induced LTP did not. In the present study, PGi-induced potentiation of spike amplitude on the saline pipette wasnormal after HE-induced saturation of spike amplitude potentiation, suggesting that the mechanisms for expression of spike potentiation, as well as induction of spike potentiation, are separate for HF and NE stimulation. Hippocampus 2001;11:322-328. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/05/20 alle ore 15:22:20