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Titolo:
Computational model of carbachol-induced delta, theta, and gamma oscillations in the hippocampus
Autore:
Tiesinga, PHE; Fellous, JM; Jose, JV; Sejnowski, TJ;
Indirizzi:
Salk Inst Biol Studies, Sloan Ctr Theoret Neurobiol, La Jolla, CA 92037 USA Salk Inst Biol Studies La Jolla CA USA 92037 biol, La Jolla, CA 92037 USA Salk Inst Biol Studies, Computat Neurobiol Lab, La Jolla, CA 92037 USA Salk Inst Biol Studies La Jolla CA USA 92037 Lab, La Jolla, CA 92037 USA Northeastern Univ, Dept Phys, Boston, MA 02115 USA Northeastern Univ Boston MA USA 02115 iv, Dept Phys, Boston, MA 02115 USA Northeastern Univ, Ctr Interdisciplinary Res Complex Syst, Boston, MA 02115 USA Northeastern Univ Boston MA USA 02115 Complex Syst, Boston, MA 02115 USA Northeastern Univ, Dept Phys, Boston, MA 02115 USA Northeastern Univ Boston MA USA 02115 iv, Dept Phys, Boston, MA 02115 USA Univ Calif San Diego, Dept Biol, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 t Biol, La Jolla, CA 92093 USA
Titolo Testata:
HIPPOCAMPUS
fascicolo: 3, volume: 11, anno: 2001,
pagine: 251 - 274
SICI:
1050-9631(2001)11:3<251:CMOCDT>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEMBRANE-POTENTIAL OSCILLATIONS; RESPIRATORY RHYTHM GENERATION; VOLTAGE-CLAMP ANALYSIS; PRE-BOTZINGER COMPLEX; RAT HIPPOCAMPUS; PYRAMIDAL CELLS; IN-VITRO; CHOLINERGIC INDUCTION; CA3 REGION; NORADRENERGIC MODULATION;
Keywords:
acetylcholine; synchronization; neuromodulation; noise; subthreshold oscillations;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
102
Recensione:
Indirizzi per estratti:
Indirizzo: Tiesinga, PHE Salk Inst Biol Studies, Sloan Ctr Theoret Neurobiol, 10010 NTorrey Pines Rd, La Jolla, CA 92037 USA Salk Inst Biol Studies 10010 N Torrey Pines Rd La Jolla CA USA 92037
Citazione:
P.H.E. Tiesinga et al., "Computational model of carbachol-induced delta, theta, and gamma oscillations in the hippocampus", HIPPOCAMPUS, 11(3), 2001, pp. 251-274

Abstract

Field potential recordings from the rat hippocampus in vivo contain distinct frequency bands of activity, including delta (0.5-2 Hz), theta (4-12 Hz), and gamma (30-80 Hz), that are correlated with the behavioral state of the animal. The cholinergic agonist carbachol (CCH) induces oscillations in the delta (CCH-delta), theta (CCH-theta), and gamma (CCH-gamma) frequency ranges in the hippocampal slice preparation, eliciting. asynchronous CCH-theta, synchronous CCH-delta, and synchronous CCH-theta with increasing CCH concentration (Fellous and Sejnowski, Hippocampus 2000;10:187-197). In a network model of area CA3, the time scale for CCH-delta corresponded to the decay constant of the gating variable of the calcium-dependent potassium (K-AHP) current, that of CCH-theta to an intrinsic subthreshold membrane potential oscillation of the pyramidal cells, and that of CCH-gamma to the decay constant of GABAergic inhibitory synaptic potentials onto the pyramidal cells. In model simulations, the known physiological effects of carbachol on the muscarinic and K-AHP currents, and on the strengths of excitatory postsynaptic potentials, reproduced transitions from asynchronous CCH-theta to CCH-delta and from CCH-delta to synchronous CCH-theta. The simulations also exhibited the interspersed CCH-gamma /CCH-delta and CCH-gamma /CCH-theta that were observed in experiments. The model, in addition, predicted an oscillatory state with all three frequency bands present, which has not yet been observed experimentally. Hippocampus 2001;11:251-274. (C) 2001 Wiley-Liss, Inc.

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Documento generato il 21/01/20 alle ore 07:43:23