Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Role of long-term synaptic modification in short-term memory
Autore:
Kesner, RP; Rolls, ET;
Indirizzi:
Univ Utah, Dept Psychol, Salt Lake City, UT 84112 USA Univ Utah Salt LakeCity UT USA 84112 ychol, Salt Lake City, UT 84112 USA Univ Oxford, Dept Expt Psychol, Oxford OX1 3UD, England Univ Oxford Oxford England OX1 3UD Expt Psychol, Oxford OX1 3UD, England
Titolo Testata:
HIPPOCAMPUS
fascicolo: 3, volume: 11, anno: 2001,
pagine: 240 - 250
SICI:
1050-9631(2001)11:3<240:ROLSMI>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
ASPARTATE RECEPTOR ANTAGONISTS; SPATIAL LOCATION INFORMATION; PARIETAL CORTEX LESIONS; CA3 PYRAMIDAL CELLS; RADIAL-ARM MAZE; WORKING-MEMORY; RECOGNITION MEMORY; HIPPOCAMPAL-FORMATION; NMDA-ANTAGONIST; INTRAHIPPOCAMPAL INJECTIONS;
Keywords:
working memory; short-term memory; long-term synaptic modification; AP5; learning; performance; spatial context; temporal context; auto associative memory; attractor neural networks; hippocampus; CA3 region of the hippocampus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
72
Recensione:
Indirizzi per estratti:
Indirizzo: Kesner, RP Univ Utah, Dept Psychol, 380 S 1530 E,Room 502, Salt Lake City,UT 84112 USA Univ Utah 380 S 1530 E,Room 502 Salt Lake City UT USA 84112 USA
Citazione:
R.P. Kesner e E.T. Rolls, "Role of long-term synaptic modification in short-term memory", HIPPOCAMPUS, 11(3), 2001, pp. 240-250

Abstract

One way that some types of short-term or working memory may be implementedin the brain is by using autoassociation networks that recirculate information to maintain the firing of a subset of neurons in what is termed an attractor state. We describe how long-term synaptic modification is necessary to set up the appropriate stable attractors, each one of which corresponds to a memory of a particular item. Once the synapses have been modified, anyof the short-term memory states may be triggered by an appropriate input which starts the neurons firing in one of the attractors, and then the firing is maintained in that attractor by the already modified synapses, with nofurther synaptic modification necessary. This analysis leads to the prediction that if this type of implementation is used for working memory, then long-term synaptic modification may be necessary only during an acquisition phase of a task, and once the task has been acquired, the performance of the working memory task should be unimpaired if no further synaptic modification is allowed. We show that a considerable body of research findings on the effects of agents that block synaptic modification on working memory tasks can be understood in this way. Many of the findings are consistent with the hypothesis that blocking synaptic modification in the hippocampus impairs the acquisition, but not the later performance, of hippocampal-dependent working memory tasks. Hippocampus 2001;11:240-250. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 16:23:30