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Titolo:
Allelic loss on chromosome bands 13q1 1-q13 in esophageal squamous cell carcinoma
Autore:
Li, G; Hu, N; Goldstein, AM; Tang, ZZ; Roth, MJ; Wang, QH; Dawsey, SM; Han, XY; Ding, T; Huang, J; Giffen, C; Taylor, PR; Emmert-Buck, MR;
Indirizzi:
Shanxi Canc Hosp, Taiyuan, Shanxi, Peoples R China Shanxi Canc Hosp Taiyuan Shanxi Peoples R China Shanxi, Peoples R China NCI, Canc Prevent Studies Branch, Bethesda, MD 20892 USA NCI Bethesda MD USA 20892 Prevent Studies Branch, Bethesda, MD 20892 USA Chinese Acad Med Sci, Canc Inst & Hosp, Beijing 100037, Peoples R China Chinese Acad Med Sci Beijing Peoples R China 100037 037, Peoples R China Informat Management Serv Inc, Silver Spring, MD USA Informat Management Serv Inc Silver Spring MD USA Silver Spring, MD USA
Titolo Testata:
GENES CHROMOSOMES & CANCER
fascicolo: 4, volume: 31, anno: 2001,
pagine: 390 - 397
SICI:
1045-2257(200108)31:4<390:ALOCB1>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
LASER CAPTURE MICRODISSECTION; TUMOR-SUPPRESSOR GENES; SUSCEPTIBILITY GENE; HETEROZYGOSITY; CANCER; IDENTIFICATION; NEOPLASIA; CLONING; REGIONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Taylor, PR NCI, Canc Prevent Studies Branch, 6006 Execut Plaza,Rm 321, Bethesda, MD 20892 USA NCI 6006 Execut Plaza,Rm 321 Bethesda MD USA 20892 MD 20892 USA
Citazione:
G. Li et al., "Allelic loss on chromosome bands 13q1 1-q13 in esophageal squamous cell carcinoma", GENE CHROM, 31(4), 2001, pp. 390-397

Abstract

Allelic loss on chromosome 13 occurs frequently in esophageal squamous cell carcinoma. However, studies of the two known tumor suppressor genes located on 13q, RBI and BRCA2, have shown few mutations, suggesting that other genes are likely to be involved in the development of this tumor type. To identify a minimal deletion interval, we first analyzed 42 microsatellite markers spanning chromosome bands 13q11-q13 in 56 esophageal squamous cell carcinoma patients, including 34 with a family history of upper gastrointestinal cancer and 22 without a family history of cancer. Lifestyle risk factorsand clinical/pathologic characteristics were also collected. Two commonly deleted regions were identified: one was located on band 13q12.11, between markers D13S787 and D13S221; the other was located on bands 13q12.3-q13.1 from markers D13S267 to D13S219. We observed higher allelic loss frequenciesfor eight of the microsatellite markers in those patients with a family history of upper gastrointestinal cancer compared to patients without such a history. This study suggests that one or more unidentified tumor suppressorgenes are located on chromosome arm 13q that play a role in the development of esophageal squamous cell carcinoma. (C) 2001 Wiley-Liss, Inc.

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Documento generato il 19/09/20 alle ore 17:38:21