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Titolo:
Calcium and the control of mammalian cortical granule exocytosis
Autore:
Abbott, AL; Ducibella, T;
Indirizzi:
Tufts Univ, Sch Med, Dept Obstet & Gynecol, Boston, MA 02111 USA Tufts Univ Boston MA USA 02111 ept Obstet & Gynecol, Boston, MA 02111 USA Tufts Univ, Sackler Sch Grad Biomed Sci, Dept Anat & Cell Biol, Boston, MA02111 USA Tufts Univ Boston MA USA 02111 Dept Anat & Cell Biol, Boston, MA02111 USA New England Med Ctr, Boston, MA 02111 USA New England Med Ctr Boston MA USA 02111 and Med Ctr, Boston, MA 02111 USA
Titolo Testata:
FRONTIERS IN BIOSCIENCE
, volume: 6, anno: 2001,
pagine: D792 - D806
SICI:
1093-9946(200107)6:<D792:CATCOM>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-KINASE-C; SEA-URCHIN EGGS; ADRENAL CHROMAFFIN CELLS; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTORS; NUCLEAR-ENVELOPE BREAKDOWN; INTRACELLULAR FREE CALCIUM; LONG-TERM POTENTIATION; FERTILIZED MOUSE EGGS; II MUTANT MICE; MEIOTIC MATURATION;
Keywords:
cortical granule; exocytosis; secretion; calcium; fertilization; mammal; egg; zona pellucida; review;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
180
Recensione:
Indirizzi per estratti:
Indirizzo: Ducibella, T Tufts Univ, Sch Med, Dept Obstet & Gynecol, 136 Harrison Ave,Boston, MA 02111 USA Tufts Univ 136 Harrison Ave Boston MA USA 02111 MA 02111 USA
Citazione:
A.L. Abbott e T. Ducibella, "Calcium and the control of mammalian cortical granule exocytosis", FRONT BIOSC, 6, 2001, pp. D792-D806

Abstract

At fertilization, the release of intracellular calcium is necessary and sufficient for most, if not virtually all, of the major events of egg activation that are responsible for the onset of embryonic development. In mammalian eggs, repetitive calcium oscillations stimulate egg activation events through calcium-dependent effectors, such as calmodulin, protein kinases, andspecific proteins involved in exocytosis. One of the earliest calcium-dependent events is the exocytosis of cortical granules (CGs), a secretory event resulting in the block to polyspermy and the prevention of triploidy. Emerging studies suggest that CG release in mature eggs is dependent upon calcium-dependent proteins similar to those in somatic cells employed to undergo calcium-regulated exocytosis. In contrast, pre-ovulatory oocytes are incompetent to undergo CG exocytosis due to deficiencies in the ability to release and respond to increases in intracellular calcium. The development of competence to release and respond to calcium is relevant to both animal and human in vitro fertilization programs that largely utilize ovarian oocytes not all of which are fully activation competent.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 00:54:24