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Titolo:
PKC in eggs and embryos
Autore:
Eliyahu, E; Kaplan-Kraicer, R; Shalgi, R;
Indirizzi:
Tel Aviv Univ, Sackler Fac Med, Dept Embryol, IL-69978 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-69978 mbryol, IL-69978 Tel Aviv, Israel
Titolo Testata:
FRONTIERS IN BIOSCIENCE
, volume: 6, anno: 2001,
pagine: D785 - D791
SICI:
1093-9946(200107)6:<D785:PIEAE>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-KINASE-C; CORTICAL GRANULE EXOCYTOSIS; REPETITIVE CALCIUM TRANSIENTS; CELL-CYCLE ACTIVATION; MOUSE EGGS; PHORBOL ESTER; INOSITOL 1,4,5-TRISPHOSPHATE; MAMMALIAN EGG; ZONA-PELLUCIDA; CA2+ RELEASE;
Keywords:
PKC; egg; activation; fertilization; review;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
72
Recensione:
Indirizzi per estratti:
Indirizzo: Shalgi, R Tel Aviv Univ, Sackler Fac Med, Dept Embryol, IL-69978 Tel Aviv,Israel Tel Aviv Univ Tel Aviv Israel IL-69978 -69978 Tel Aviv, Israel
Citazione:
E. Eliyahu et al., "PKC in eggs and embryos", FRONT BIOSC, 6, 2001, pp. D785-D791

Abstract

After a spermatozoon enters the egg, rapid processes such as the cortical granules exocytosis (CGE) occur. Other, later processes are observed as well, and they include resumption of the second meiotic division, second polarbody (PBII) extrusion and rearrangement of the DNA inside the pronuclei (PN). The above mentioned biochemical processes involve signal transduction pathways that are well known in other cell systems, and require mediation ofsecond messengers like Ca2+ and diacylglycerol (DAG) which are protein kinase C (PKC) activators. The present review, based upon recently published studies, raises the possibility of PKC involvement in fertilization and in early developmental stages of the mammalian embryo.

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Documento generato il 20/01/21 alle ore 01:33:22