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Titolo:
The pH-dependent inhibitory action of n-butyrate on gastrointestinal epithelial cell division
Autore:
Galfi, P; Neogrady, S;
Indirizzi:
Szent Istvoan Univ, Fac Vet Sci, Dept Physiol & Biochem, H-1400 Budapest, Hungary Szent Istvoan Univ Budapest Hungary H-1400 hem, H-1400 Budapest, Hungary
Titolo Testata:
FOOD RESEARCH INTERNATIONAL
fascicolo: 7, volume: 34, anno: 2001,
pagine: 581 - 586
SICI:
0963-9969(2001)34:7<581:TPIAON>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
SODIUM NORMAL-BUTYRATE; CHAIN FATTY-ACIDS; INTRACELLULAR PH; NA+/H+ EXCHANGE; PRIMARY CULTURE; SHEEP RUMEN; DIFFERENTIATION; PROLIFERATION; GROWTH; DIET;
Keywords:
gastrointestinal epithelial cells; rumen epithelial cells; rumen connective tissue cells; cell proliferation; pH dependency; short-chain fatty acids; butyrate; H-3-deoxythymidine-incorporation; bromdeoxyuridine-labeling; Na-uptake;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Galfi, P Szent Istvoan Univ, Fac Vet Sci, Dept Physiol & Biochem, POB 2, H-1400 Budapest, Hungary Szent Istvoan Univ POB 2 Budapest Hungary H-1400 dapest, Hungary
Citazione:
P. Galfi e S. Neogrady, "The pH-dependent inhibitory action of n-butyrate on gastrointestinal epithelial cell division", FOOD RES IN, 34(7), 2001, pp. 581-586

Abstract

The four-carbon fatty acid, n-butyrate is an inhibitor of cell division invitro, but surprisingly in vivo n-butyrate is a stimulator of the gastrointestinal cell growth. In order to find any explanation of this discrepancy,our experiments were carried out in rumen epithelial cell (REC) and rumen connective tissue cell (RCTC) cultures at different pH values after n-butyrate addition, and the rate of cellular DNA synthesis was measured. The D-glucose and Na-n-butyrate metabolism, further the Na+/H+ exchange of the cells were also determined at different pH values. It was established that the cell division inhibitory action of n-butyrate in the REC, but not in the RCTC is a pi-I-dependent process, and the changing metabolism and transport processes of REC at different pH values can contribute in abrogating of the inhibitory action of butyrate. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 16:13:16