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Titolo:
Effects of lower doses of conjugated equine estrogens and medroxyprogesterone acetate on plasma lipids and lipoproteins, coagulation factors, and carbohydrate metabolism
Autore:
Lobo, RA; Bush, T; Carr, BR; Pickar, JH;
Indirizzi:
Columbia Presbyterian Med Ctr, Dept Obstet & Gynecol, New York, NY 10032 USA Columbia Presbyterian Med Ctr New York NY USA 10032 ew York, NY 10032 USA Univ Maryland, Sch Med, Dept Epidemiol & Prevent Med, College Pk, MD 20742USA Univ Maryland College Pk MD USA 20742 revent Med, College Pk, MD 20742USA SW Texas State Univ, Med Ctr, Dept Obstet & Gynecol, San Marcos, TX 78666 USA SW Texas State Univ San Marcos TX USA 78666 col, San Marcos, TX 78666 USA
Titolo Testata:
FERTILITY AND STERILITY
fascicolo: 1, volume: 76, anno: 2001,
pagine: 13 - 24
SICI:
0015-0282(200107)76:1<13:EOLDOC>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
HORMONE-REPLACEMENT THERAPY; CORONARY HEART-DISEASE; V-LEIDEN MUTATION; POSTMENOPAUSAL WOMEN; CARDIOVASCULAR-DISEASE; RISK-FACTORS; INSULIN SENSITIVITY; MENOPAUSAL WOMEN; PERSPECTIVE; PROGESTIN;
Keywords:
conjugated equine estrogens (CEE); medroxyprogesterone acetate (MPA); lower doses; women's HOPE study; hormone replacement therapy (HRT); lipoproteins; lipids; coagulation; carbohydrate metabolism;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Lobo, RA Columbia Presbyterian Med Ctr, Dept Obstet & Gynecol, 622 West 168th St,Room 1630 East, New York, NY 10032 USA Columbia Presbyterian Med Ctr622 West 168th St,Room 1630 East New York NY USA 10032
Citazione:
R.A. Lobo et al., "Effects of lower doses of conjugated equine estrogens and medroxyprogesterone acetate on plasma lipids and lipoproteins, coagulation factors, and carbohydrate metabolism", FERT STERIL, 76(1), 2001, pp. 13-24

Abstract

Objective: To determine the effects of lower doses of conjugated equine estrogens (CEE) alone or CEE and medroxyprogesterone acetate (MPA) on lipoproteins, carbohydrate metabolism, and coagulation/fibrinolytic factors. Design: Randomized, double-blind, placebo-controlled study. Setting: Multicenter substudy of the Women's HOPE trial. Patient(s): Seven hundred and forty-nine healthy, postmenopausal women. Intervention(s): Women were randomized to receive the following doses in milligrams per day: 0.625 CEE; 0.625 CEE/2.5 MPA; 0.45 CEE; 0.45 CEE/2.5 MPA; 0.45 CEE/1.5 MPA; 0.3 CEE; 0.3 GEE/1.5 MPA; or placebo. Main Outcome Measure(s): Assessment of lipids, lipoproteins, glucose tolerance, and coagulation/fibrinolytic factors at baseline, cycle 6, and year 1. Result(s): One year of treatment with any of the CEE or CEE/MPA regimens studied increased high-density lipoprotein cholesterol (HDL-C); the 10% increase in HDL-C for the CEE 0.45/MPA 1.5 group was similar to the CEE 0.625/MPA 2.5 group. Low-density lipoprotein cholesterol was significantly reducedin all of the active treatment groups except the CEE 0.3/MPA 1.5 group at cycle 13. Apolipoprotein A-I and triglyceride levels increased and apolipoprotein B levels decreased in all groups. The lipoprotein (a) level was reduced in the CEE 0.45/MPA 2.5, CEE 0.45/MPA 1.5, and CEE 0.625/MPA 2.5 groups. Minimal changes were observed in carbohydrate metabolism for all groups. Fibrinogen and PAI-1 activity decreased and plasminogen activity increased in all groups. Decreases in antithrombin III and protein S activities were significant for all active treatment groups except the CEE 0.3/MPA 1.5 group. Conclusion(s): Lower doses of CEE and CEE/MPA induce favorable changes in lipids, lipoproteins, and hemostatic factors with minimal changes in carbohydrate metabolism. (C) 2001 by American Society for Reproductive Medicine.

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Documento generato il 22/01/20 alle ore 18:35:02