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Titolo:
Role of cytokines in endometriosis
Autore:
Harada, T; Iwabe, T; Terakawa, N;
Indirizzi:
Tottori Univ, Sch Med, Dept Obstet & Gynecol, Yonago, Tottori 6838504, Japan Tottori Univ Yonago Tottori Japan 6838504 Yonago, Tottori 6838504, Japan
Titolo Testata:
FERTILITY AND STERILITY
fascicolo: 1, volume: 76, anno: 2001,
pagine: 1 - 10
SICI:
0015-0282(200107)76:1<1:ROCIE>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
NECROSIS-FACTOR-ALPHA; MONOCYTE CHEMOTACTIC PROTEIN-1; ENDOTHELIAL GROWTH-FACTOR; HUMAN PERITONEAL-MACROPHAGES; KILLER-CELL ACTIVITY; STROMAL CELLS; IN-VITRO; UNEXPLAINED INFERTILITY; MILD ENDOMETRIOSIS; MENSTRUAL-CYCLE;
Keywords:
cytokine; macrophage; endometriosis; peritoneal fluid;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
106
Recensione:
Indirizzi per estratti:
Indirizzo: Harada, T Tottori Univ, Sch Med, Dept Obstet & Gynecol, Yonago, Tottori 6838504, Japan Tottori Univ Yonago Tottori Japan 6838504 ottori 6838504, Japan
Citazione:
T. Harada et al., "Role of cytokines in endometriosis", FERT STERIL, 76(1), 2001, pp. 1-10

Abstract

Objective: To review the literature on the role of cytokines in the pathogenesis of endometriosis and endometriosis-associated infertility. Design: Pertinent studies were identified by a computer search of MEDLINE. References of selected articles were hand-searched for additional citations. Result(s): Recent studies suggest that the peritoneal fluid of women with endometriosis contains an increased number of activated macrophages that secrete various local products, such as growth factors and cytokines. Levels of several cytokines were reported to be elevated in the peritoneal fluid of women with endometriosis. Because the peritoneal environment may be controlled by locally regulated factors, cytokines are believed to play a role in the development and progression of endometriosis and endometriosis-associated infertility. A possible pathogenic mechanism Links cytokines with endometriosis. Conclusion(s): Cytokines, which are produced by many cell types including endometriotic tissues, play diverse roles in the pathogenesis of endometriosis and endometriosis-associated infertility. More studies about the specific role of these cells and soluble factors are needed to improve understanding of endometriosis and to develop novel therapies. (C) 2001 by American Society for Reproductive Medicine.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 06:00:02