Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Expression of membrane C1q in human monocyte-derived macrophages is developmentally regulated and enhanced by interferon-gamma
Autore:
Kaul, M; Loos, M;
Indirizzi:
Univ Mainz, Inst Med Microbiol & Hyg, D-55101 Mainz, Germany Univ Mainz Mainz Germany D-55101 Microbiol & Hyg, D-55101 Mainz, Germany
Titolo Testata:
FEBS LETTERS
fascicolo: 1-2, volume: 500, anno: 2001,
pagine: 91 - 98
SICI:
0014-5793(20010629)500:1-2<91:EOMCIH>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
COMPLEMENT COMPONENT C1Q; CULTURED HUMAN-MONOCYTES; IN-SITU HYBRIDIZATION; 1ST COMPONENT; MONOCLONAL-ANTIBODIES; FUNCTIONAL-PROPERTIES; SUBCOMPONENT C1Q; DENDRITIC CELLS; BLOOD MONOCYTES; FC-RECEPTORS;
Keywords:
monocyte/macrophage; differentiation; complement; C1q; phagocytosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Loos, M Univ Mainz, Inst Med Microbiol & Hyg, Hochhaus Augustuspl, D-55101Mainz, Germany Univ Mainz Hochhaus Augustuspl Mainz Germany D-55101 inz, Germany
Citazione:
M. Kaul e M. Loos, "Expression of membrane C1q in human monocyte-derived macrophages is developmentally regulated and enhanced by interferon-gamma", FEBS LETTER, 500(1-2), 2001, pp. 91-98

Abstract

The present study investigated when during 'in vitro' maturation macrophages (M Phi) express membrane C1q (mC1q), and whether cell activation affectsexpression and function of mC1q, Although C1q mRNA was repeatedly detectedin freshly isolated monocytes using reverse transcriptase-polymerase chainreaction, Clq protein mas observed only in developing M Phi from day 1 to 4 on using immunodetection and flow cytometry, However, the quantity of mC1q and other M Phi membrane proteins differed strikingly in cells from different donors. We report here for the first time that CD14(+) and CD14(-) mC1q-bearing M Phi can develop, and that interferon-gamma increases mC1q display at the cell surface, and mC1q-mediated phagocytosis, (C) 2001 Published by Elsevier Science B,V, on behalf of the Federation of European Biochemical Societies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 06:09:28