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Titolo:
Peroxynitrile decomposition catalysts and methods of use thereof
Autore:
;
Titolo Testata:
EXPERT OPINION ON THERAPEUTIC PATENTS
fascicolo: 7, volume: 11, anno: 2001,
pagine: 1229 - 1231
SICI:
1354-3776(200107)11:7<1229:PDCAMO>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
HYDROXYL RADICAL PRODUCTION; NITRIC-OXIDE; SUPEROXIDE; ACID; OXIDATIONS; NO;
Keywords:
Alzheimer's disease; cerebrovascular ischaemia; motor neurone disease;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
EXPERT OP T, 11(7), 2001, pp. 1229-1231

Abstract

Novel metal complexes of macrocyclic ligands, particularly substituted porphyrin, porphyrazine, texaphyrin, salen and corrole complexes and methods of their use for lowering peroxynitrite (PN) levels in the treatment of Alzheimer's disease, amyotrophic lateral sclerosis, stroke, AIDS dementia, Huntington's chorea, atherosclerosis, chronic inflammation, autoimmune disease,cancer, ischaemia-reperfusion injury, septic shock and chronic graft rejection are claimed. These metallic peroxynitrite decomposition catalysts are stated to have a high catalytic activity, high in vivo stability and half-life, an optimised tissue distribution and a low toxicity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 04:44:42