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Titolo:
Phospholipase A(2) inhibitors in inflammation
Autore:
Lehr, M;
Indirizzi:
Univ Munster, Inst Pharmaceut Chem, D-48149 Munster, Germany Univ MunsterMunster Germany D-48149 ceut Chem, D-48149 Munster, Germany
Titolo Testata:
EXPERT OPINION ON THERAPEUTIC PATENTS
fascicolo: 7, volume: 11, anno: 2001,
pagine: 1123 - 1136
SICI:
1354-3776(200107)11:7<1123:PAIII>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
ARACHIDONIC-ACID RELEASE; FLUORESCENCE-BASED ASSAY; HUMAN SYNOVIAL-FLUID; CYTOSOLIC PHOSPHOLIPASE-A2; RECOMBINANT EXPRESSION; PROSTAGLANDIN E(2); POTENT INHIBITOR; GROUP-IIA; CELLS; CALCIUM;
Keywords:
asthma; inflammation; inhibitors; neurodegenerative diseases; phospholipase A(2); septic shock;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
78
Recensione:
Indirizzi per estratti:
Indirizzo: Lehr, M Univ Munster, Inst Pharmaceut Chem, Hitorfstr 58-62, D-48149 Munster, Germany Univ Munster Hitorfstr 58-62 Munster Germany D-48149 ter, Germany
Citazione:
M. Lehr, "Phospholipase A(2) inhibitors in inflammation", EXPERT OP T, 11(7), 2001, pp. 1123-1136

Abstract

The key reaction of the arachidonic acid cascade is the liberation of arachidonic acid from membrane phospholipids by a phospholipase A(2) (PLA(2)). An excessive stimulation of this biochemical pathway leads to the formationof pathophysiological concentrations of lipid mediators like prostaglandins, leukotrienes, lysophospholipids and platelet activating factor, which are implicated in the development of inflammatory conditions. Thus, inhibitors of PLA(2) are expected to be a new treatment option for such diseases. One problem associated with the in vitro search for PLA(2) inhibitors is the selection of the appropriate enzyme, since many different PLA(2)s are present in the mammalian organism. This paper discusses which of these PLA(2)s is most likely to play the major role in the generation of the pro-inflammatory lipid mediators. Furthermore, patents claiming inhibitors of PLA(2)s for the prevention and treatment of inflammation are reviewed for the period January 1997 to December 2000.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 23:26:31