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Titolo:
Growth factor regulation and manipulation in wound repair: to scar or not to scar, that is the question
Autore:
Krein, PM; Huang, Y; Winston, BW;
Indirizzi:
Univ Calgary, Dept Med, Calgary, AB T2N 4N1, Canada Univ Calgary Calgary AB Canada T2N 4N1 t Med, Calgary, AB T2N 4N1, Canada Univ Calgary, Dept Biochem & Mol Biol, Div Crit Care Med, Calgary, AB T2N 4N1, Canada Univ Calgary Calgary AB Canada T2N 4N1 e Med, Calgary, AB T2N 4N1, Canada Univ Calgary, Immunol Res Grp, Calgary, AB T2N 4N1, Canada Univ Calgary Calgary AB Canada T2N 4N1 s Grp, Calgary, AB T2N 4N1, Canada
Titolo Testata:
EXPERT OPINION ON THERAPEUTIC PATENTS
fascicolo: 7, volume: 11, anno: 2001,
pagine: 1065 - 1079
SICI:
1354-3776(200107)11:7<1065:GFRAMI>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
IDIOPATHIC PULMONARY FIBROSIS; BRONCHOALVEOLAR LAVAGE FLUID; FACTOR-BETA; FACTOR-I; FACTOR-ALPHA; FACTOR EXPRESSION; TGF-BETA; ALVEOLAR MACROPHAGES; FACTOR RECEPTOR; FIBROBLAST GROWTH-FACTOR-2;
Keywords:
fibroproliferation; growth factors; pulmonary fibrosis; wound healing;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
143
Recensione:
Indirizzi per estratti:
Indirizzo: Winston, BW Univ Calgary, Dept Med, Room 1843,3330 Hosp Dr NW, Calgary, ABT2N 4N1, Canada Univ Calgary Room 1843,3330 Hosp Dr NW Calgary AB Canada T2N 4N1
Citazione:
P.M. Krein et al., "Growth factor regulation and manipulation in wound repair: to scar or not to scar, that is the question", EXPERT OP T, 11(7), 2001, pp. 1065-1079

Abstract

The process of tissue repair following injury is in the large part mediated by secreted growth factors which, in an autocrine or paracrine fashion, stimulate immune and mesenchymal cells at the site of injury. The complex process of replacing damaged tissue with newly formed tissue involves components of the blood, coagulation, immune and mesenchymal systems as well as cytokines, chemokines, metalloproteinases and growth factors. This review will focus on growth factors as the controllers of this process and includes members of the transforming growth factor (TGF), platelet derived growth factor (PDGF), fibroblast growth factor (FGF), connective tissue derived growth factor (CTCF) and insulin-like growth factor-I (IGF-I) families of growthfactors. These growth factors stimulate re-epithelialisation, angiogenesis, extracellular matrix (ECM) formation and cell proliferation each of whichplays a role in tissue replacement and restoration of tissue function following injury. Normal wound healing frequently involves the formation of scar tissue, including increased mesenchymal cell proliferation and excessive production of ECM proteins. While scar tissue rapidly and effectively closes wounds, it leaves visually apparent tissue structure changes and may reduce the function of the tissue leading to compromised organ function. Growthfactors, the conductors of these processes, are targets for therapeutic manipulation of wound healing and scar formation. Recent patents involving growth factors may be implicated in the treatment of wound healing following tissue injury. Enhanced growth factor activity may be beneficial to increase the rate of wound healing in chronic non-healing wounds, whereas reduction of growth factor presence or activity may reduce scar formation in the skin and internal organs, which may be particularly relevant where scar formation is associated with pathologic loss of life sustaining organ function.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 07:15:34