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Titolo:
Cardiovascular response to graded lower body negative pressure in young and elderly man
Autore:
van Hoeyweghen, R; Hanson, J; Stewart, MJ; Dethune, L; Davies, I; Little, RA; Horan, MA; Kirkman, E;
Indirizzi:
Univ Manchester, Dept Geriatr Med, Manchester, Lancs, England Univ Manchester Manchester Lancs England Med, Manchester, Lancs, England Univ Manchester, N Western Injury Res Ctr, Manchester, Lancs, England UnivManchester Manchester Lancs England Ctr, Manchester, Lancs, England Univ Manchester, Sch Biol Sci, Manchester, Lancs, England Univ ManchesterManchester Lancs England Sci, Manchester, Lancs, England N Manchester Gen Hosp, Manchester, Lancs, England N Manchester Gen Hosp Manchester Lancs England anchester, Lancs, England Univ Durham, Dept Biol Sci, Durham, England Univ Durham Durham EnglandUniv Durham, Dept Biol Sci, Durham, England Univ Durham, Sch Hlth, Durham, England Univ Durham Durham EnglandUniv Durham, Sch Hlth, Durham, England
Titolo Testata:
EXPERIMENTAL PHYSIOLOGY
fascicolo: 3, volume: 86, anno: 2001,
pagine: 427 - 435
SICI:
0958-0670(200105)86:3<427:CRTGLB>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
STROKE DISTANCE; CARDIOPULMONARY BAROREFLEXES; ARGININE-VASOPRESSIN; SYMPATHETIC ACTIVITY; FOREARM VASODILATOR; SENIEUR PROTOCOL; HEALTHY-SUBJECTS; BLOOD-PRESSURE; AGE; CATECHOLAMINES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Kirkman, E Univ Manchester, Dept Geriatr Med, Manchester, Lancs, England Univ Manchester Manchester Lancs England ster, Lancs, England
Citazione:
R. van Hoeyweghen et al., "Cardiovascular response to graded lower body negative pressure in young and elderly man", EXP PHYSIOL, 86(3), 2001, pp. 427-435

Abstract

Lower body negative pressure (LBNP) reduces central venous pressure (CVP) and cardiac output. The elderly are reported to have a limited capacity to increase cardiac output by increasing heart rate (HR), are especially dependent on end diastolic volume to maintain stroke volume and therefore shouldbe especially vulnerable to LBNP. The present study compared the effects of LBNP in the young and old. Stroke volume was assessed non-invasively as stroke distance (SD) by aortovelography. Two groups of healthy male volunteers were studied: eight young (29.7 +/-2.0 years, mean +/- S.E.M.) and nine old (70.1 +/-0.9 years). LBNP was applied progressively at 17.5, 35 and 50 mmHg in 20 min steps, with measurements taken during each steady state. There were similar, significant, falls in CVP in both groups. SD fell significantly in both groups from respective control values of 24.8 +/-1.6 and 16.6+/-0.9 cm to 12.5 +/-1.3 and 8.9 +/-0.4 cm at a LBNP of 50 mmHg. Although SD in the elderly was significantly lower than in the young, the LBNP-induced changes were not different between groups. Both groups produced similar significant increases in vascular resistance, HR, plasma vasopressin (AVP) and noradrenaline. Mean arterial blood pressure (MBP) and plasma adrenalinedid not change significantly. Therefore healthy old men respond to LBNP ina similar manner to the young, although MBP and SD are regulated around different baselines in the two groups.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 07:37:26