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Titolo:
Pulmonary immunity to ragweed in a Beagle dog model of allergic asthma
Autore:
Redman, TK; Rudolph, K; Barr, EB; Bowan, LE; Muggenburg, BA; Bice, DE;
Indirizzi:
Lovelace Resp Res Inst, Albuquerque, NM 87185 USA Lovelace Resp Res Inst Albuquerque NM USA 87185 Albuquerque, NM 87185 USA
Titolo Testata:
EXPERIMENTAL LUNG RESEARCH
fascicolo: 5, volume: 27, anno: 2001,
pagine: 433 - 451
SICI:
0190-2148(200107/08)27:5<433:PITRIA>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED AIRWAY HYPERRESPONSIVENESS; TERM ANTIBODY-PRODUCTION; BRONCHIAL RESPONSIVENESS; LUNG TRANSPLANTATION; RESPIRATORY-DISEASE; LYMPHOCYTES-T; ATOPIC ASTHMA; EOSINOPHILS; RESPONSES; POLLUTION;
Keywords:
airway reactivity; canine allergy model; eosinophils; IgE; pulmonary immunity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Bice, DE Lovelace Resp Res Inst, POB 5890, Albuquerque, NM 87185 USA Lovelace Resp Res Inst POB 5890 Albuquerque NM USA 87185 7185 USA
Citazione:
T.K. Redman et al., "Pulmonary immunity to ragweed in a Beagle dog model of allergic asthma", EXP LUNG R, 27(5), 2001, pp. 433-451

Abstract

To create an allergy model in the dog, allergic Beagles with high levels of serum immunoglobulin E (IgE) and eosinophilia were bred; resulting puppies were sensitized to ragweed by intraperitoneal (IP) injection within 24 hours of birth through 22 weeks of age. At least 50% of the puppies developedhigh levels of serum IgE and eosinophilia. As young adults, 6 of these dogs, and 6 control age-matched, nonallergic, nonimmunized dogs were exposed by inhalation to ragweed twice at 13-day intervals, and a third time 45 dayslater. Total and ragweed-specific serum IgE and ragweed-specific serum IgEwere increased significantly in allergic dogs relative to baseline. Allergic dogs had significantly greater levels of antibody specific for ragweed, as well as higher eosinophil counts in the bronchoalveolar lavage fluid, compared to nonallergic dogs. Airway reactivity to histamine in allergic, butnot nonallergic dogs, increased significantly after aerosol exposure to ragweed. After a third exposure to ragweed, airway responses to histamine were elevated in the allergic dogs and remained high for at least 5 months. These results demonstrate the potential of the allergic dog model for investigating the underlying pulmonary immune mechanisms and therapeutic treatmentof allergic asthma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/02/20 alle ore 08:52:17