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Titolo:
Role of intercellular adhesion molecule 1 in acute lung injury induced by candidemia
Autore:
Yokomura, I; Iwasaki, Y; Nagata, K; Nakanishi, M; Natsuhara, A; Harada, H; Kubota, Y; Ueda, M; Inaba, T; Nakagawa, M;
Indirizzi:
Kyoto Prefectural Univ Med, Dept Med 2, Kamigyo Ku, Kyoto 6028566, Japan Kyoto Prefectural Univ Med Kyoto Japan 6028566 Ku, Kyoto 6028566, Japan Kyoto Prefectural Univ Med, Dept Clin Lab & Med, Kamigyo Ku, Kyoto 6028566, Japan Kyoto Prefectural Univ Med Kyoto Japan 6028566 Ku, Kyoto 6028566, Japan
Titolo Testata:
EXPERIMENTAL LUNG RESEARCH
fascicolo: 5, volume: 27, anno: 2001,
pagine: 417 - 431
SICI:
0190-2148(200107/08)27:5<417:ROIAM1>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIAL-CELLS; P-SELECTIN; IC3B RECEPTOR; ALBICANS; EXPRESSION; MICE; LOCALIZATION; LEUKEMIA; LIGANDS; ADULTS;
Keywords:
acute lung injury; candidemia; intercellular adhesion molecule 1 (ICAM-1); rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Yokomura, I Kyoto Prefectural Univ Med, Dept Med 2, Kamigyo Ku, 465 Kajiicho,Kawaramachi Hirokoji, Kyoto 6028566, Japan Kyoto Prefectural Univ Med 465 Kajiicho,Kawaramachi Hirokoji Kyoto Japan 6028566
Citazione:
I. Yokomura et al., "Role of intercellular adhesion molecule 1 in acute lung injury induced by candidemia", EXP LUNG R, 27(5), 2001, pp. 417-431

Abstract

Candidemia, a complication often affecting immunocompromised patients, is a common cause of acute lung injury. Yeast-phase Candida albicans has been shown to express a protein that is antigenically and structurally related to Mac-1 C. albicans is reported to stimulate intercellular adhesion molecule 1 (ICAM-1) expression on endothelial cells. In this study, the authors examined the role of ICAM-1 in acute lung injury induced by candidemia. The authors cultured rat pulmonary artery endothelial cells (RPAEC) and investigated the effect of anti-ICAM-1 antibodies on adhesion of C. albicans to RPAEC. In addition, the authors administered anti-ICAM-1 antibodies to rats toexamine the effect of the antibodies on experimentally induced candidemia. Survival rates, lung wet-to-dry (W/D) weight ratios, bronchoalveolar lavage (BAL) fluid, histopathological findings, and colony-forming units (CFUs) of lung C.albicans were examined. The adherence of C. albicans to RPAEC wassignificantly decreased by anti-ICAM-1 antibodies. Anti-ICAN-1 antibodies significantly increased survival, decreased lung W/D weight ratios, decreased neutrophil counts in the Bal fluid, reduced microscopic lung injury, andthe quantity of the lung C. albicans. These results indicate that ICAM-11 plays a role in adherence of C. albicans to pulmonary vascular endothelial cells, which likely leads to invasion of lung tissue by the organism.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 08:44:12