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Titolo:
beta(3)-adrenoceptors control Cl- conductance in rabbit nasal epithelium
Autore:
Danner, I; Escande, D; Gauthier, C;
Indirizzi:
Hotel Dieu, INSERM, U533, Lab Physiopathol & Pharmacol Cellulaires & Mol, F-44093 Nantes, France Hotel Dieu Nantes France F-44093 llulaires & Mol, F-44093 Nantes, France Univ Nantes, Fac Sci & Tech, F-44035 Nantes, France Univ Nantes Nantes France F-44035 Fac Sci & Tech, F-44035 Nantes, France
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 1-3, volume: 422, anno: 2001,
pagine: 203 - 207
SICI:
0014-2999(20010622)422:1-3<203:BCCCIR>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
ATYPICAL BETA-ADRENOCEPTOR; CYSTIC-FIBROSIS; RECEPTOR; STIMULATION; MECHANISM; PATHWAY; KINASE;
Keywords:
nasal epithelium rabbit; transepithelial potential difference; beta(3)-adrenoceptor; Cl- conductance;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Gauthier, C Hotel Dieu, INSERM, U533, Lab Physiopathol & Pharmacol Cellulaires & Mol, F-44093 Nantes, France Hotel Dieu Nantes France F-44093 Mol, F-44093 Nantes, France
Citazione:
I. Danner et al., "beta(3)-adrenoceptors control Cl- conductance in rabbit nasal epithelium", EUR J PHARM, 422(1-3), 2001, pp. 203-207

Abstract

We have investigated the effects of beta (3)-adrenoceptor stimulation in vivo on nasal epithelium. We have recorded the transepithelial potential difference in New Zealand white rabbit nostrils. Superfusion of the nasal epithelial surface with a Cl--free medium supplemented with amiloride, hyperpolarized the nasal potential difference. Isoprenaline produced a hyperpolarization of the nasal potential difference that was not prevented by nadolol, a potent beta (1)-/beta (2)-adrenoceptor antagonist, but was abolished by bupranolol, a nonselective beta (1-3)-adrenoceptor antagonist. SR 58611 ((RS)-N-[(25)-7-ethoxycarbonylmethoxy- 1,2,3,4-teuahydronapht-2-yl-(2R)-2-(3-chlorophenyl)-2 hydroethanamine hydrochloride) and CGP 12177 (4-[3-t-butylamino-3-hydroxypropoxy]benzimidazol-2-1), a preferential and a partial beta (3)-adrenoceptor agonists, respectively, also produced hyperpolarization of the nasal potential difference. SR 59230 (3-(2-ethylphenoxy)-1-[(1S)1,2,3,4-tetrahydronaphth-1-ylaminol]-(2S)-2-propanol oxalate), a selective beta (3)-adrenoceptor antagonist, abolished the effects of CGP 12177. We conclude that beta (3)-adrenoceptor stimulation resulted in modifications in the nasal potential difference. These findings strengthen the view that beta (3)-adrenoceptors are implicated in controlling water and salt transport in the normal respiratory epithelium. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 05:29:44